(November 15, 2024)
Solhyd not only develops technology to produce hydrogen from air and sunlight. We also develop methods to produce that technology in a cost-effective and reliable manner. Efficient production, with cost reductions driven by scale benefits, will eventually lead to the lowest cost approach to make hydrogen from solar energy.
We took the first step in that process this year.
(02 October 2019)
For over a decade, Professor Johan Martens and Drs. Tom Bosserez, Jan Rongé and Christos Trompoukis have been developing a ‘solar hydrogen panel’, i.e. a solar panel that can create hydrogen from the water vapour in the air. Using sunlight, moisture taken from the air – i.e. no liquid water – is split into hydrogen on the one hand, and oxygen molecules on the other.
The panel is able to directly convert no less than 15 per cent of sunlight into hydrogen gas, Which is a world record
(19.09.2023)
Die Suche nach den Ursachen für genetische Erkrankungen ist ein großes Unterfangen, bei dem vermehrt auch künstliche Intelligenz (KI) zum Einsatz kommt. Ein neues KI-Werkzeug von Google DeepMind kann das Krankheitsrisiko abschätzen, das von bestimmten Genmutationen ausgeht. Die entstandene Datenbank soll künftige Untersuchungen zur Entstehung der Krankheiten deutlich erleichtern.
(19.09.2023)
Google DeepMind has developed a new tool called AlphaMissense, which uses the AlphaFold human protein structure models to predict whether a sequence variant which changes one amino acid in a protein is likely to be tolerated or to impact protein function.
The Ensembl Variant Effect Predictor now integrates Google DeepMind’s new AlphaMissense Catalogue.
Google DeepMind has developed an AI system that predicts the chances that tens of millions of genetic variants will cause disease.
(10 May 2023)
The work was led by the international Human Pangenome Reference Consortium (HPRC), a group funded by the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH) and consisting of 14 institutes, including EMBL’s European Bioinformatics Institute (EMBL-EBI). (…)
The majority of the genomes used to create the human pangenome reference were collected as part of the 1000 genomes project, the largest public catalogue of human variation and genotype data from a wide range of populations. (…)
In order to understand the differences in the genes present across the individual genomes represented in the human pangenome, researchers in EMBL-EBI’s Ensembl team needed to map the high-quality annotations on the reference human genome generated as part of the GENCODE project, across the pangenome.
Some genomic differences may not affect fitness. Neutral variation, previously thought to be “junk” DNA, is unaffected by natural selection resulting in higher genetic variation at such sites when compared to sites where variation does influence fitness.[14]
It is not fully clear how natural selection has shaped population differences; however, genetic candidate regions under selection have been identified recently. (…)
It was found that on average, each person carries around 250–300 loss-of-function variants in annotated genes and 50-100 variants previously implicated in inherited disorders. Based on the two trios, it is estimated that the rate of de novo germline mutation is approximately 10−8 per base per generation.
(Dec 2015)
“Now this is not the end… But it is, perhaps, the end of the beginning” as Winston Churchill said. Large-scale sequencing projects will continue for more regional or ethnic groups, in order to extend the global coverage. Much effort will focus on a better understanding of the relationship between genetic variation and common disorders. The translation of this massive genetic information to human health will benefit from the development of complex databases gathering genetic, clinical, and biological data, such as multi-omics profiles, while maintaining protection of potentially sensitive personal information (3). Efforts are also underway to increase genetic awareness in the public and to educate health professionals
The goal of the GENCODE project is to identify and classify all gene features in the human and mouse genomes with high accuracy based on biological evidence, and to release these annotations for the benefit of biomedical research and genome interpretation.
(25 April 2023)
EMBL-EBI Director Ewan Birney was a graduate student in the 90s, when the Human Genome Project was in full swing. On the project’s 20th anniversary, he shares his memories of the slow but incredibly accurate analysis software he developed, how the private initiative sped up the public one, and how a betting book highlighted how little we knew about the human genome at the time.
(22 July 2021)
For those scientists who rely on experimental protein structure determination, AlphaFold’s predictions have helped accelerate their research. For example, a team at the University of Colorado Boulder is finding promise in using AlphaFold predictions to study antibiotic resistance, while a group at the University of California San Francisco has used them to increase their understanding of SARS-CoV-2 biology.
The AlphaFold Protein Structure Database builds on many contributions from the international scientific community, as well as AlphaFold’s sophisticated algorithmic innovations and EMBL-EBI’s decades of experience in sharing the world’s biological data. DeepMind and EMBL’s European Bioinformatics Institute (EMBL-EBI) are providing access to AlphaFold’s predictions so that others can use the system as a tool to enable and accelerate research and open up completely new avenues of scientific discovery.
(October 20, 2014)
One day, as I surfed the web on my laptop and lamented how long it takes a YouTube video to load, I found myself wondering if employees of the US government — DoD researchers, DoE scientists, CIA spies — are also beholden to the same congestion and shoddy peering that affects everyone else on the internet. Surely, as hundreds of scientists at Fermi Lab near Chicago wait for petabytes of raw data to arrive from the Large Hadron Collider in Europe, they don‘t suffer interminable connection drops and inexplicable lag. And, as it turns out, they don‘t: the US government and its national laboratories all have exclusive access to ESnet — a shadow internet that can sustain 100-gigabits-per-second transfers between any of the major Department of Energy labs. And today, the DoE announced that the 100-gigabit ESnet will be extended across the Atlantic to our Old World comrades, who occasionally manage to dazzle us with their scientific endeavors.
Häufig liest man an vielerlei Stellen, die Pandemie sei geplant gewesen. Belege dafür liefert kaum jemand. Es scheint an der Zeit, einmal zu fragen, wer denn überhaupt ein Motiv dafür gehabt haben könnte.
(April 19, 2023 )
EcoHealth Alliance’s $3.3 million grant to fund a project titled “Understanding the Risk of Coronavirus Emergence” was initially to run from October 1, 2013, to September 30, 2018. The first “Project/Performance Site Location” is the Wuhan Institute of Virology. Three other Chinese sites follow: East China Normal University in Shanghai, Yunnan Institute of Endemic Disease Control and Prevention in Dali, and the Center for Disease Control and Prevention of Guangdong in Guangzhou.
On May 27, 2014, the NIH awarded EcoHealth Alliance $3,086,735 over five years for “Understanding the Risk of Bat Coronavirus Emergence.”
An EcoHealth Alliance grant application, received by the NIH on June 5, 2013, includes a list of “Senior/Key Personnel” including Shi Zhengli and Zhang Yun-Zhi of the Wuhan Institute of Virology (WIV); Peter Daszak, CEO of EcoHealth Alliance; and other Chinese scientists, including Ke Changwen of the Chinese “CDC and Prevention of Guangdong Province.”
In der Periode der zweiten Obama-Präsidentschaft (2012-2016) war nach heftigen Debatten um „GoF“ die bundesstaatliche Förderung dafür mit Gültigkeit ab 2014 vorerst ausgesetzt worden – ein zeitweiliges „Moratorium“. Ein eigenes Verfahren zum Genehmigen von Vorhaben mit „besonders riskanten“ Mikroben sollte entwickelt werden. (2) Das setzte Grenzen für den Fortgang der Vorhaben an Barics UNC-Instituten für Virologie und Epidemiologie. Zur Hilfe kam eine Absprache zur Zusammenarbeit mit dem WIV, vermittelt durch die New Yorker Organisation „EcoHealth Alliance“ und deren Chef Peter Daszak, die dafür gerade noch rechtzeitig eine Finanzierung seitens NIH/NIAID beantragt hatte, die dann von Faucis NIAID ebenfalls noch 2013 für fünf Jahre ab 2014 genehmigt wurde.
(Oct 7, 2019)
The research, according to the team, will help monitor and evaluate the influence of solar activities and their implications on the Earth’s climate. The astrophysicists’ team included experts from Ahmedabad’s Physical Research Laboratory (PRL), Japan, and China.
(2010)
Abstract. The heliosphere is the space within which the solar wind dominates and the solar interplanetary magnetic field prevails. Its boundary is determined by the balance between stellar and solar winds. Owing to the present reduction in the solar wind pressure, one would expect that the stellar wind would push the heliosphere inward leading to its shrinkage. In this paper we calculate the extent of the heliosphere at different solar wind status.
Backward estimation of the extent of the heliosphere since 1890 is done. It is found that the heliosphere oscillated between 75 and 125 AU between 1890 –
2010. Most important is the forecast of the shrinkage and oscillations of the heliosphere and their implications on the earth. The shrinkage of the heliosphere would allow more invasions of cosmic rays to the earth and planets, increased cloud cover and a cooler Earth.
1 Introduction
The heliosphere is the cavity curved by the solar wind into the interstellar medium. Its extension is determined by the equality of the solar wind pressure and the stellar wind pressure. For this reason, we will first study past, present and future status of solar activity and then we will reflect this study into the heliosphere.
(18.10.2008)
New data has revealed that the heliosphere, the protective shield of energy that surrounds our solar system, has weakened by 25 per cent over the past decade and is now at it lowest level since the space race began 50 years ago. (…)
„Around 90 per cent of the galactic cosmic radiation is deflected by our heliosphere, so the boundary protects us from this harsh galactic environment.“
The heliosphere is created by the solar wind, a combination of electrically charged particles and magnetic fields that emanate a more than a million miles an hour from the sun, meet the intergalactic gas that fills the gaps in space between solar systems.
If the world’s propagandizing ‘news’ outlets insist on reporting that Antarctica sea ice is melting in oblivion–which NASA reveals it most certainly isn’t–then they need to come up with a new mechanism to support it, because temperatures, clearly, are playing no part.
(June 5, 2019)
Google‘s Craig Gidney and KTH‘s Martin Ekera demonstrated that a quantum system could crack 2,048-bit RSA encryption with just 20 million quantum bits (qubits), rather than requiring 1 billion qubits as previously theorized, in only eight hours with this technique.
The technique uses modular exponentiation, a mathematical process for finding the remainder when a number is raised to a certain power and divided by another number.
Gidney and Ekera have formulated various ways to optimize this process, reducing the resources required to run the large-number-factoring Shor‘s algorithm.
(October 2021)
Accurate estimates of COVID vaccine-induced severe adverse event and death rates are critical for risk-benefit ratio analyses of vaccination and boosters against SARS-CoV-2 coronavirus in different age groups. However, existing surveillance studies are not designed to reliably estimate life-threatening event or vaccine-induced fatality rates (VFR). Here, regional variation in vaccination rates was used to predict all-cause mortality and non-COVID deaths in subsequent time periods using two independent, publicly available datasets from the US and Europe (month-and week-level resolutions, respectively). Vaccination correlated negatively with mortality 6-20 weeks post-injection, while vaccination predicted all-cause mortality 0-5 weeks post-injection in almost all age groups and with an age-related temporal pattern consistent with the US vaccine rollout. Results from fitted regression slopes (p<0.05 FDR corrected) suggest a US national average VFR of 0.04% and higher VFR with age (VFR=0.004% in ages 0-17 increasing to 0.06% in ages >75 years), and 146K to 187K vaccine-associated US deaths between February and August, 2021.
(December 2021)
At first glance the ONS data suggest that, in each of the older age groups, all-cause mortality is lower in the vaccinated than the unvaccinated. Despite this apparent evidence to support vaccine effectiveness-at least for the older age groups-on closer inspection of this data, this conclusion is cast into doubt because of a range of fundamental inconsistencies and anomalies in the data. Whatever the explanations for the observed data, it is clear that it is both unreliable and misleading. While socio-demographical and behavioural differences between vaccinated and unvaccinated have been proposed as possible explanations, there is no evidence to support any of these. By Occam‘s razor we believe the most likely explanations are systemic miscategorisation of deaths between the different categories of unvaccinated and vaccinated; delayed or non-reporting of vaccinations; systemic underestimation of the proportion of unvaccinated; and/or incorrect population selection for Covid deaths.
(Published: 13 September 2021)
Here, we show that a high-resolution calculation succeeds in reproducing the solar-like differential rotation. Our calculations indicate that the strong magnetic field generated by a small-scale dynamo has a significant impact on thermal convection. The successful reproduction of the differential rotation, convection and magnetic field achieved in our calculation is an essential step to understanding the cause of the most basic nature of solar activity, specifically, the 11 yr cycle of sunspot activity.
(08.11.2021)
Japanese scientists said they have created the first accurate computer simulation of how the Sun rotates, reproducing a phenomenon in which its equatorial area spins faster than its polar regions. The insight could help explain the whys and hows of the solar cycle, one of the biggest mysteries of our star.
Die Konferenz Nr. 14 bietet alte und beliebte Bekannte; darüberhinaus aber auch viele neue Gesichter. Vorträge werden gehalten von:
James Taylor (Heartland Institute, USA)
Prof. Dr. Horst-Joachim Lüdecke (Pressesprecher, EIKE)
Prof. Dr. Peter Ridd (Australien)
Prof. Dr. William Happer (USA)
Dr. habil. Sebastian Lüning (Kalte Sonne)
Prof. Dr. Ana G. Elias (Argentinien)
Prof. Dr. Henrik Svensmark (Dänemark) & Prof. Dr. Nir Shaviv (Israel)
Dr. Susan Crockford (Kanada)
Prof. em. Dr. Christian Schlüchter (Schweiz)
Prof. Dr. Richard Lindzen (USA)
Prof. Dr. Maria da Assunção Araújo (Portugal)
Dr. Bernd Fleischmann (Deutschland)
Dipl.-Ing. Michael Limburg (Vizepräsident, EIKE)
Prof. Dr. Valentina Zharkova (Vereinigtes Königreich)
Prof. Dr. Nicola Scafetta (Italien)
Prof. Dr. John R. Christy (USA)
Prof. Dr. Fritz Vahrenholt (Kalte Sonne)
Prof. Dr. László Csaba Szarka (Ungarn)
Dr. Götz Ruprecht, Institut für Festkörper-Kernphysik gGmbH (Deutschland)
Solange das Erdöl sprudelt, erforscht man, erfindet man und meldet Patente an. Mn schöpft aus, was die Erdöl-abhängige Welt hergibt und wenn die Zeit reif ist, keine Sekunde früher, baut man um. Schön im Tackt, Stück für Stück, so, dass dem alten alles abgetrotzt werden kann, was in ihm steckt, aber das neue in fließendem Übergang auf sichere Fundamente gestellt wird und „sicher“ meint: unter der Kontrolle und zum Wohle der Dynasti
The objective of Global Britain is not to swagger or strike attitudes on the world stage. It is to use the full spectrum of our abilities, now amplified by record spending on both defence and science, to engage with and help the rest of the world. That is how we serve the British interest, and I mean the economic interest of people up and down the country. And as the vaccine programme begins to inspire a new global hope, we want to use this moment to heal, both literally and figuratively.
Mit dem Aktionsplan sollen die Bereiche Weltraum, Verteidigung und zivile Forschung zunehmend verwoben werden, was zu einer weiteren Militarisierung der Wissenschaft beitragen dürfte.
(22.12.2020)
Laut Alina Chan, Molekularbiologin am Broad Institute of Harvard und am MIT, kann man die Evolution von SARS-CoV-2 nicht mit der These eines zoonotischen Ursprungs in Einklang bringen, denn das Virus war bereits vollständig für die Mensch-zu-Mensch-Übertragung angepasst, als es zum ersten Mal auftrat.
Die renommierte medizinische Fachzeitschrift „Nature“ erlaubte anscheinend einigen Autoren, ihre Daten heimlich zu ändern, ohne auf diese Korrekturen in den Artikeln hinzuweisen.
Chans Untersuchungen zeigen, dass die Autoren ihre Proben umbenannt, falsch zugeordnet und ein Genomprofil generiert haben, das mit keiner ihrer Proben übereinstimmt. In anderen Papers fehlen Daten.
Das Coronavirus RaTG13, zu 96 Prozent mit SARS-CoV-2 identisch und somit der engste Verwandte, ist in Wirklichkeit btCoV-4991. Dieses Genom wurde schon 2013 in Proben nachgewiesen und 2016 veröffentlicht.
(11.09.2020)
– According to Alina Chan, a molecular biologist at the Broad Institute of Harvard and MIT, SARS-CoV-2 did not evolve in a manner you’d expect, had it jumped from an animal to a human. It sprang into action fully evolved for human transmission
– It appears Nature, a top medical journal, has allowed authors to secretly alter data sets in their papers without publishing notices of correction
– Chan’s investigation reveals authors have renamed samples, failed to attribute them properly, and produced a genomic profile that doesn’t match the samples in their paper. Others are missing data
– RaTG13 — the coronavirus that most resembles SARS-CoV-2, being 96% identical — is actually btCoV-4991, a virus found in samples collected in 2013 and published in 2016
– If SARS-CoV-2, the virus responsible for COVID-19 and the subsequent response to it, came from a lab, then we need to reassess the future of gain-of-function research that allows for the weaponization of viruses
(25 Oct 20)
Since the outbreak in late 2019, events have been unfolding at such a fast pace that it is difficult to keep track of what happened and in what order.
I use visualizations of the timeline to follow key events relating to the search for the animal host of SARS2. (2/30)
Even today, I still hear people saying that SARS-CoV-2 came from pangolins and a Seafood market in Wuhan. I hope this analysis will help to clear things up. It will refresh us on significant early pandemic events and major publications discussing the origins of the virus (3/30).
(Jul 07, 2020)
In early February 2019, Dr. Shi’s team suddenly tossed a brand new genome online and published a paper, citing that hCoV-2019 must come from (horseshoe) Bats because it is so similar to this other sample obtained from Bats in July 2013.
*If an existing genome was already in the system and the new data was uploaded we would expect to see reference notes and that the previous listing had been removed or updated.
*The scientists were forcing an argument that this newly published genome (RaTG13) came from a Bat and is the closest relative to hCoV-2019, therefore our pandemic virus more than likely came from a bat.
At the time of this publication, there is quite literally zero record or publication referencing this sudden new virus that they designated as Bat SL-CoV RaTG13 (Ra being Rhinolophus affinis, 13 being sampling year). How could this new virus have been just ABSENT from the scientific community for SEVEN YEARS?!
In fact, there are (comparatively) barely any Rhinolophus Affinis Samples in our databases. Meaning there is a small pool or Bat viruses from this specific species. The team simply renamed the sample and maybe forgot that 4991 was already in GenBank?! Because 4991 is actually RaTG13, yet this super important publication which was read by all of the top scientists in the world makes zero mention of this important fact.
(May 02, 2020)
Abstract: In a side-by-side comparison of evolutionary dynamics between the 2019/2020 SARS-CoV-2 and the 2003 SARS-CoV, we were surprised to find that SARS-CoV-2 resembles SARS-CoV in the late phase of the 2003 epidemic after SARS-CoV had developed several advantageous adaptations for human transmission. Our observations suggest that by the time SARS-CoV-2 was first detected in late 2019, it was already pre-adapted to human transmission to an extent similar to late epidemic SARS-CoV. However, no precursors or branches of evolution stemming from a less human-adapted SARS-CoV-2-like virus have been detected. The sudden appearance of a highly infectious SARS-CoV-2 presents a major cause for concern that should motivate stronger international efforts to identify the source and prevent near future re-emergence.
The initial supplies of Oxford-AstraZeneca vaccine have been produced by a company called Halix in the Netherlands.
Once produced in bulk, the vaccine goes to a plant in Wrexham, run by an Indian company called Wockhardt, where it is decanted into vials in a process known as ‚fill and finish‘. The plant can bottle at least 150,000 doses a day.
– Blood samples unveiled this week show people in California, Oregon and Washington infected in December
– Further tests on blood taken in mid-to-late December and into early January found virus in six more states
– Italy, Brazil and France have all since found traces of the virus before China even acknowledged it existed
– Evidence has emerged in Spain and the UK suggesting that Covid-19 was around before testing was possible
– Claims the virus emerged in a market in Wuhan last winter have crumbled in the face of scientific evidence
Heute fand ein erster Prozess gegen die Menschen statt, die vor einem Jahr im Tübinger Gemeinderat gegen das Amazon-Entwicklungszentrum im Cyber Valley protestiert hatten. Betroffen war ein IMI-Beirat und -Autor. Wir dokumentieren hier Beiträge der Berichterstattung aus dem Prozess und von der Solidaritäts-Kundgebung.
Science is being suppressed for political and financial gain. Covid-19 has unleashed state corruption on a grand scale, and it is harmful to public health.1 Politicians and industry are responsible for this opportunistic embezzlement. So too are scientists and health experts. The pandemic has revealed how the medical-political complex can be manipulated in an emergency—a time when it is even more important to safeguard science.
The UK’s pandemic response provides at least four examples of suppression of science or scientists. First, the membership, research, and deliberations of the Scientific Advisory Group for Emergencies (SAGE) were initially secret until a press leak forced transparency.
In other words, Martin keeps his characters’ networks within the limits that his readers’ human minds were designed by evolution to cope with.
Die aus Oakland (US-Bundesstaat Kalifornien) stammende Biologin war 2000 an das Max-Planck-Institut für molekulare Zellbiologie und Genetik (MPI-CBG) nach Dresden gekommen.