Archiv: (sterilizing) immunity (medical) / (sterilisierende) Immunität (medizinisch)


23.02.2021 - 11:19 [ Reuters ]

Israeli studies find Pfizer COVID-19 vaccine reduces transmission

(19.02.2021)

Findings of the pre-published study, not yet peer-reviewed, but based on a national database that is one of the world’s most advanced, were first reported by the Israeli news site Ynet late on Thursday and were obtained by Reuters on Friday.

Pfizer declined to comment and the Israeli Health Ministry did not respond to a request for comment.

23.02.2021 - 11:14 [ Radio Utopie ]

Wozu Impfpässe, wenn man nach wie vor den Virus bekommen und Andere anstecken kann?

(21.01.2021)

Alle müssen wissen, dass die in der „Europäischen Union“ zugelassenen Impfstoffe der Konzerne Pfizer / BioNTech und Moderna keine sterilisierende Immunität liefern. Nochmal: das heisst, dass diese sogenannten „Impfstoffe“ weder vor Infektion von SARS II (dem aktuellen Coronavirus), noch vor dessen Verbreitung schützen, sondern lediglich den Angaben zufolge gegen die von SARS II ausgelöste Krankheit Covid-19; und dies auch nur für eine unklare Zeitperiode. Eine Immunität gegen SARS II gibt es durch diesen Impfstoff also nicht.

15.02.2021 - 05:53 [ DailyMail.co.uk ]

Single jabs of Covid vaccine are providing 67% protection against infections, data reveals as experts say delaying second dose is ‚paying off‘

Prof Spector said that he no longer watched the Government’s daily briefings as he felt the statistics were not presented in context, particularly the death rates.

He said: ‚It’s very sad people die of anything. Yesterday around 600 people died of Covid but on a normal day in February 1,500 people die of heart disease, strokes, cancer etc or the flu.

‚This has got a lot of people extremely anxious and are petrified to leave their homes and may have problems coming out if we do not put those statistics into context.

‚People are dying of Covid but people die of other things. I would like to see less fear-mongering.‘

13.02.2021 - 19:36 [ Telegraph.co.uk ]

Oxford Covid-19 vaccine Q&A: How effective is it, and how is it different to the Pfizer vaccine?

According to new results, a single dose of the Oxford-AstraZeneca vaccine prevents two-thirds of Covid transmissions, raising hopes for the easing of restrictions by Easter.

The data, released on Feb 2, also revealed that the first jab prevents 100 per cent of hospitalisations after 22 days once an immune response has had time to develop.

13.02.2021 - 19:21 [ DailyMail.co.uk ]

Boris says he’s ‚optimistic‘ about easing lockdown starting with schools in March and we will ‚learn to live with‘ Covid – as leaked data shows hospitalisations falling much FASTER than expected

Modelling by Sage presented to Downing Street and leaked to The Times predicts hospital admissions and deaths will more than halve over the next month.

Patients battling coronavirus in hospital currently number around 24,000, but this figure is expected to be slashed to around 9,000 by mid-March.

Yesterday 1,908 patients were taken to hospital in the UK, a massive drop in admission rates since the peak in January when around 4,500 were admitted on a single day.

13.02.2021 - 19:18 [ ABC News ]

COVID-19 could become a seasonal illness like the flu, experts say

Dr. Paul Offit, director of the Vaccine Education Center and professor of pediatrics in the Division of Infectious Diseases at Children’s Hospital of Philadelphia, concurred, adding that he is also „not sure we’re ever going to really eliminate this virus. … It’s not like measles, where you get life-long sterilizing immunity.“

But even if the virus sticks around, new vaccines and new drugs to fight the virus mean it’s unlikely to cause severe illness in the future. Offit predicts „that eventually, it will cause fewer deaths than influenza.“

11.02.2021 - 09:54 [ Tagesschau.de ]

113 Menschen nach Impfung verstorben: Fachleute geben dennoch Entwarnung

In einigen Senioreneinrichtungen kam es zudem kurz nach der Impfung zu Corona-Ausbrüchen. In einem Alten- und Pflegeheim in Leverkusen starben 18 Bewohnerinnen und Bewohner, auch in Uhldingen-Mühlhofen am Bodensee starben bereits Geimpfte an dem Virus. Sie waren wohl schon zum Zeitpunkt der Impfung unerkannt infiziert oder die Infizierung hat kurz danach stattgefunden.

07.02.2021 - 22:28 [ Massachusetts Institute of Technology (MIT) ]

So you got the vaccine. Can you still infect people? Pfizer is trying to find out.

(02.02.2021)

Whether or not the vaccines stop “onward transmission” of the virus is likely to be a critical variable in determining how the pandemic plays out and how soon life goes back to normal. Right now, researchers say, their best guess is that vaccines will reduce transmission but may not prevent it entirely.

07.02.2021 - 22:24 [ Radio Utopie ]

Warum der Pfizer / BioNTech „Impfstoff“ ein gigantischer Betrug und zudem gefährlich ist

(4.Dezember 2020)

1. Dieser sogenannte „Impfstoff“ schützt weder vor Infektion von SARS II (dem aktuellen Coronavirus), noch vor dessen Verbreitung. Er schützt, heisst es, lediglich vor der Krankheit Covid-19. Und das auch nur ca. 3 Monate. Es können allerdings trotzdem „Symptome“ wie Müdigkeit auftreten. Eine Immunität gegen SARS II gibt es durch diesen Impfstoff nicht.

Über diese Informationen herrscht weltweit faktisch Nachrichtensperre.

07.02.2021 - 21:21 [ Times of Israel ]

TV: Several vaccinated elderly tested positive for COVID, but had no symptoms

Pfizer and Moderna, which produce the vaccines used in Israel, have said their shots appear to be slightly less effective in preventing the so-called South African strain of the virus, though the companies say they remain quite potent.

07.02.2021 - 21:15 [ KTOO.org ]

Juneau nursing home outbreak could be a model for what COVID-19 looks like after vaccine

(07.02.2021)

Staff and outside experts attribute the health of these people in the face of their COVID-19 infections primarily to the Pfizer and Moderna vaccines. Nearly 80% of the people who live and work in the facility have received at least one of the shots in the two-shot series.

07.02.2021 - 21:00 [ NDR ]

Belm: 14 geimpfte Seniorenheim-Bewohner positiv getestet

Geimpft worden sei mit dem Produkt von Biontech/Pfizer.

07.02.2021 - 15:40 [ University of Oxford ]

Oxford coronavirus vaccine shows sustained protection of 76% during the 3-month interval until the second dose

(02.02.2021)

The authors also report further on the potential for the vaccine to reduce transmission of the virus, based on swabs obtained from volunteers in the UK arms of the trial with a 67% reduction after the first dose of the vaccine.

05.02.2021 - 21:16 [ theSun.co.uk ]

UK Covid cases fall by a THIRD in a week and deaths down almost 20% piling pressure on Boris to show way out of lockdown

Mark Harper — chairman of the Covid Recovery Group of lockdown sceptics, with 70 Tory MPs — said: “Back-of-the-envelope calculations I did based on two million doses a week mean you could get the top nine priority groups, first doses, and the top four groups, second doses, all done by the end of May.

“So it seems to me by the time you get to the end of May, no later than that, you should be in a position to get rid of restrictions completely.

05.02.2021 - 09:35 [ Tagesschau.de ]

ARD-DeutschlandTrend: Mehrheit gegen Erleichterungen für Geimpfte

Trotz aller geäußerter Sorgen wird die Notwendigkeit der Corona-Maßnahmen von einer Mehrheit nicht infrage gestellt: 51 Prozent bezeichnen die aktuellen Einschränkungen als angemessen, für 24 Prozent gehen sie nicht weit genug.

04.02.2021 - 21:16 [ Roland Imhoff / Twitter ]

Tochter (8): „Papa kann man, wenn man gegen Corona geimpft ist, das eigentlich noch weitergeben?“. Wenn ein Kind versteht, dass es wichtig ist, ob eine Impfung sterilisierende Immunität erzeugt, dann sollten das auch diejenigen Erwachsenen, die Rockkonzerte für Geimpfte fordern.

04.02.2021 - 21:10 [ ORF.at ]

Deutscher Ethikrat gegen Sonderbehandlung Geimpfter

Der deutsche Ethikrat hat sich gegen staatliche Sonderregeln für CoV-Geimpfte ausgesprochen. Der Hauptgrund sei die Unsicherheit, ob Geimpfte weitere Personen anstecken könnten, sagte die Vorsitzende des Ethikrates, Alena Buyx, heute in Berlin.

02.02.2021 - 23:55 [ Social Science Research Network ]

Single dose administration, and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine

If there was no impact of a vaccine on asymptomatic infection, it would be expected that an efficacious vaccine would simply convert severe cases to mild cases and mild cases to asymptomatic, with overall PCR positivity unchanged. A measure of overall PCR positivity is appropriate to assess whether there is a reduction in the burden of infection. Analyses presented here show that a single standard dose of the vaccine reduced PCR positivity by 67%, and that, after the second dose, the SD/SD schedule reduced PCR positivity by 49.5% overall. These data indicate that ChAdOx1 nCoV-19, used in the authorised schedules, may have a substantial impact on transmission by reducing the number of infected individuals in the population.

02.02.2021 - 23:55 [ DailyMail.co.uk ]

Single shot of Oxford University’s Covid jab ‚is 76% effective for 12 weeks and may block seven in 10 people from spreading the disease‘

Meanwhile, analysis of PCR positive swabs carried out on nearly 7,000 patients in the UK arm of Oxford’s trial suggests the vaccine may reduce transmission by 67 per cent.

01.02.2021 - 20:30 [ Washington Post ]

Why Vaccines Might Not Be Able to Eliminate Covid-19

There’s good evidence that the shots made by Pfizer Inc.-BioNTech SE and Moderna Inc. are very effective — as much as 95% — at preventing recipients from developing Covid-19 itself. However, data haven’t been released on their ability to prevent people from developing asymptomatic infections or transmitting the virus to others. The gold standard in vaccinology is to stop infection as well as disease, providing so-called sterilizing immunity.

31.01.2021 - 20:24 [ VeryWellHealth.com ]

Sterilizing Immunity and COVID-19 Vaccines

As game-changing as the Pfizer vaccine (and Moderna’s equally effective mRNA-1273 vaccine) may be in affording protection against the COVID-19 illness, the results do not reflect complete „sterilizing immunity.“

This is the type of immunity that completely prevents a disease-causing pathogen like COVID-19 from establishing an infection. Sterilizing immunity differs from effective immunity in that the latter can prevent illness but still lead to asymptomatic infection.

31.01.2021 - 20:14 [ DailyBeast.com ]

Rep. Stephen Lynch Contracts COVID After Two Pfizer Vaccine Doses

Rep. Stephen Lynch (D-MA) announced late Friday that he had tested positive for COVID-19 more than a week after receiving his second dose of the Pfizer coronavirus vaccine.

28.01.2021 - 16:21 [ DailyMail.co.uk ]

Vaccines WILL limit the spread of coronavirus – but we won’t know by how much until mid-February, experts say

Another burning question which will determine how gung-ho ministers can be with easing restriction is to what extent the vaccines stop people from spreading Covid.

The Government has commissioned a study to investigate the vaccines and their role on transmission, which is being overseen by Public Health England. It is focused on frontline healthcare workers who’ve been jabbed.

25.01.2021 - 06:44 [ Telegraph.co.uk ]

Vaccine passports supported by majority of public despite ‚dystopian‘ consequences

(24.01.2021)

Two polls conducted in April found that between 51 and 70 per cent of people were likely to support these passports.

25.01.2021 - 06:40 [ Telegraph.co.uk ]

Vaccine passports make no sense if the Covid jabs don’t stop you spreading the virus

(12.01.2021)

Until we know for sure whether the vaccines stop transmission, it’s best to leave the passport idea to science fiction writers

23.01.2021 - 19:56 [ theHill.com ]

Pfizer chairman: We’re not sure if someone can transmit virus after vaccination

(DEc 3, 2020)

Pfizer chairman Albert Bourla told Dateline host Lester Holt that the pharmaceutical company was “not certain” if the vaccine prevented the coronavirus from being transmitted, saying, “This is something that needs to be examined.”

23.01.2021 - 19:49 [ CNN ]

Unlocking the World: What ‚vaccine passports‘ mean for your summer vacation

This week, Zurab Pololikashvili, the secretary general of the United Nations World Tourism Organization, called for the global adoption of vaccination passports as part of wider measures he said were essential to get the world in motion once again.
„The rollout of vaccines is a step in the right direction, but the restart of tourism cannot wait,“ he told a meeting of the UNWTO’s Global Tourism Crisis Committee in Madrid. „Vaccines must be part of a wider, coordinated approach that includes certificates and passes for safe cross-border travel.“

22.01.2021 - 17:13 [ ZDF ]

Lambrecht: Geimpften Grundrechte zurückgeben

Umgekehrt gelte aber auch: „Solange nicht wissenschaftlich sicher belegt ist, dass die Impfung auch vor einer Weitergabe des Virus schützt, kommt eine unterschiedliche Behandlung von Geimpften gegenüber Nicht-Geimpften nicht in Frage.“

Außenminister Heiko Maas (SPD) hatte die Debatte zuletzt erneut eröffnet, als er der „Bild am Sonntag“ sagte: „Geimpfte sollten wieder ihre Grundrechte ausüben dürfen.“

21.01.2021 - 19:15 [ Radio Utopie ]

Wozu Impfpässe, wenn man nach wie vor den Virus bekommen und Andere anstecken kann?

Alle müssen wissen, dass die in der „Europäischen Union“ zugelassenen Impfstoffe der Konzerne Pfizer / BioNTech und Moderna keine sterilisierende Immunität liefern. Nochmal: das heisst, dass diese sogenannten „Impfstoffe“ weder vor Infektion von SARS II (dem aktuellen Coronavirus), noch vor dessen Verbreitung schützen, sondern lediglich den Angaben zufolge gegen die von SARS II ausgelöste Krankheit Covid-19; und dies auch nur für eine unklare Zeitperiode. Eine Immunität gegen SARS II gibt es durch diesen Impfstoff also nicht.

19.01.2021 - 17:36 [ DerbyShireTimes.co.uk ]

Derbyshire health chiefs warn that vaccines alone will not mean an end to restrictions

“We don’t know yet whether an individual can, although not becoming ill from the virus because they have been vaccinated, still catch it and spread it on to others.

19.01.2021 - 17:24 [ Standard.co.uk ]

Vaccinated Brits told not to hug kids amid fears millions will ignore Covid rules once they have jab

Asked whether people who had received the jab could hug their children, Janet Lord, director of Birmingham University’s Institute of Inflammation and Ageing, said: “I would certainly advise not to do that at the moment because as you probably know with the vaccines they take several weeks before they are maximally effective.“

19.01.2021 - 17:20 [ bestlifeonline.com ]

The COVID Vaccine May Not Protect You From This One Thing, Experts Warn

(05.12.2020)

In order to halt the spread of coronavirus completely, a vaccine would need to produce antibodies that stop the virus from replicating. „To prevent asymptomatic infection and transmission, you need what’s called sterilizing immunity,“ Greg Poland, MD, director of the Mayo Clinic’s Vaccine Research Group, explained to USA Today. While it’s possible that one or more of the vaccines could produce sterilizing immunity, it currently remains unproven.

15.01.2021 - 17:48 [ Sydney Morning Herald ]

Protection versus immunity: the great vaccination debate

That issue had been quietly bubbling away for months as animal and human trial data pointed to difficulties in making vaccines that achieve „sterilising immunity“ – total immunity from infection, versus immunity from getting seriously ill.

Concerns circulated among scientists and doctors on social media.

14.01.2021 - 10:32 [ Heise.de ]

Neuartige mRNA-Impfstoffe gegen Corona?

Telepolis hat den beiden deutschen mRNA-Impfstoffentwicklern BioNTech in Mainz und CureVac in Tübingen die folgende Frage gestellt: Welche Wirkung ist bei der Impfstoffentwicklung beabsichtigt und wird in der Folge in den Studien überprüft?

Thorsten Schüller, Vice President Communications bei CureVac lässt sich dazu mit den folgenden Worten zitieren:

Das Ziel der Studien ist es, eine schwerwiegende Erkrankung an COVID-19 zu verhindern. Die sterile Immunität und/oder die Transmission müssen in Studien noch getestet werden, dazu ist ein spezielles Studiendesign notwendig.

14.01.2021 - 09:52 [ .LancashireTelegraph.co.uk ]

Those who have received Covid jab to be offered ‚vaccine passport‘ in new trial

The news comes depsite the Vaccines Minister, Nadhim Zahawi, ruling out immunity passports back in December, a week after suggesting it was something ministers were considering, saying: “We are not looking at immunity passports at all.”

Matt Hancock also denied plans to implement passporting last week, telling the Spectator: „It’s not an area that we’re looking at.“

14.01.2021 - 09:30 [ Public Health England / Twitter ]

Even if you’ve had your #COVID19 vaccine, it’s important that you continue to follow national restrictions. We don’t yet know if the vaccine prevents transmission – you could potentially still carry and transmit the virus to other vulnerable people, even if you are protected

13.01.2021 - 18:30 [ Nature.com ]

UK science advisers: publish evidence behind COVID vaccine changes

Pfizer–BioNTech say they do not have evidence of what happens to immunity beyond 21 days after the first dose.

(…)

The JCVI adds that: “Protective immunity from the first dose likely lasts for a duration of 12 weeks.” But it has not published evidence to support this.

13.01.2021 - 18:12 [ voanews.com ]

US Changes Vaccine Strategy, WHO Says Herd Immunity Will Not Be Achieved in 2021

Meanwhile, the World Health Organization is warning that mass vaccinations against the novel coronavirus will not produce herd immunity this year.

WHO chief scientist Dr. Soumya Swaminathan told reporters Monday that it takes time to produce and administer enough doses of a vaccine to finally stop the spread of COVID-19. Swaminathan stressed the need for countries to continue observing mitigation efforts such as mask-wearing, social distancing and hand-washing.

13.01.2021 - 17:57 [ theGuardian.com ]

How well does the Oxford vaccine work? What we know so far

(30.12.2020)

And while there are some early signs the Oxford/AstraZeneca vaccine might not only prevent people becoming seriously ill with Covid but also prevent asymptomatic infections, more data is needed to confirm such protection.

13.01.2021 - 17:48 [ Luzerner Zeitung ]

EU diskutiert den digitalen Impfpass – dürfen Schweizer bald nur noch mit Zertifikat ins Flugzeug?

Griechenland fordert die Einführung eines Impf-Zertifikats, um Reisen in Europa schneller möglich zu machen. Kommt der EU-Impfpass, steigt der Druck auf die Schweiz.

13.01.2021 - 17:19 [ DailyMail.co.uk ]

Thousands of Britons who have received their Covid jab ‚will be offered a vaccine passport‘ in trial taking place this month – as EU considers plan to bring them in for travel across Europe

– Thousands of Britons will be offered vaccine passes in trial starting this month
– Passport will be issued as a free app which show if people have had Covid jab
– Government agency Innovate UK has pumped £75,000 into project so far
– Vaccines tsar Nadhim Zahawi has flip-flopped over controversial policy

13.01.2021 - 17:13 [ KFL / Twitter ]

Noch keine „sterilisierende Immunität“ nachgewiesen bedeutet: Man würde zwar weniger, aber dennoch krank – und man ist vor allem ansteckend. Darum können auch nach der Impfung die Schutzmaßnahmen nicht aufgehoben werden.

(15.12.2020)

13.01.2021 - 17:11 [ Neeltje van Doremalen / Twitter ]

The data supports the investigation of intranasal delivery of COVID-19 vaccines. With the roll-out of COVID-19 vaccines worldwide, it will be crucial to investigate whether the vaccines provide sterilizing immunity…

13.01.2021 - 17:09 [ Vox.com ]

Once you and your friends are vaccinated, can you quit social distancing?

How long it takes for various countries to reach herd immunity will depend in part on how fast they can access vaccines and what share of their populations are willing to get the shot. But as mentioned above, there’s another crucial factor.

“It’s really going to come down to what we learn over the next few months about how well the vaccine prevents infection and transmission,” Murray said, adding that she doesn’t expect we’ll have an answer to that until March at the earliest.

13.01.2021 - 17:03 [ SWR.de ]

Können Geimpfte das Coronavirus weiterverbreiten?

Wichtige Fragen, bei denen Antworten noch schwerfallen.

05.01.2021 - 18:17 [ Achse des Guten ]

Die wundersame Impf-Chronologie

Spätestens mit RKI-Veröffentlichungen vom 15. April 2020 kann jeder wissen, dass das Infektionsgeschehen in Deutschland seit Mitte März rückläufig und der R-Wert schon lange unter 1 gefallen war, bevor irgendeine Staatsmaßnahme zur Eindämmung hätte entsprechend wirken können.

Erinnern wir uns an die beiden Hauptgründe sowohl für die Herbeiführung des Ausnahmezustandes als auch die Idee, Herdenimmunität durch Massenimpfung zu erzeugen. Erstens: Asymptomatisch Kontaminierte tragen wesentlich zu einem Infektions-, gar Erkrankungsgeschehen bei. Deshalb müssen auch Gesunde zueinander auf Abstand gehen. Zweitens: „SARS-CoV-2 ist so neu, dass praktisch niemand immun dagegen ist.“ (tagesschau.de, 19.3.)

Urheber beider Ideen ist Drosten.

01.01.2021 - 08:55 [ Radio Utopie ]

Wie die Briten mit der neuen Totalen Weltordnung brechen und die Aufhebung des Ausnahmezustands feiern könnten

Ich sage nicht, dass das passieren wird. Ich sage – sie könnten.

Stellt es Euch vor…

31.12.2020 - 05:26 [ theGuardian.com ]

How well does the Oxford vaccine work? What we know so far

And while there are some early signs the Oxford/AstraZeneca vaccine might not only prevent people becoming seriously ill with Covid but also prevent asymptomatic infections, more data is needed to confirm such protection.

31.12.2020 - 05:21 [ DiscoverMagazine.com ]

Will the Vaccine End the Pandemic? This Question Must Be Answered First

One key to these successes is that these vaccines provide sterilizing immunity — recipients are not infected by the viruses that cause the diseases and don’t pass it on. When a sufficiently large percentage of the population is immunized, it reaches herd immunity: the pathogen can’t find enough new hosts to keep propagating, and outbreaks peter out.

28.12.2020 - 17:24 [ .oxfordmail.co.uk ]

No herd immunity through vaccine programme before summer, Sage scientist warns

Calum Semple, professor of outbreak medicine at the University of Liverpool and a member of the Scientific Advisory Group for Emergencies (Sage), described the Oxford/AstraZeneca vaccine as a “game changer” if it is approved by the Medicines and Healthcare products Regulatory Agency (MHRA) in the coming days.

But he told BBC Breakfast…

27.12.2020 - 19:51 [ Forbes ]

What Every Vaccine Skeptic Should Know About The New Coronavirus Vaccines

What hasn’t been demonstrated, at least so far, is that these vaccines prevent you from getting infected entirely. We’ve shown that these vaccines provide neutralizing immunity, where the virus will no longer severely harm you, but not necessarily sterilizing immunity, where you cannot pass the virus onto others. Additionally, it isn’t known how long your immunity will persist. This, very importantly, means that you still need to wear a mask, wash/sanitize your hands, and practice social distancing — and to be rigorous about doing them all — for now.

23.12.2020 - 11:32 [ BBC ]

Oxford vaccine: How did they make it so quickly?

(23.11.2020)

Scientists took a common cold virus that infected chimpanzees and engineered it to become the building block of a vaccine against almost anything.

Before Covid, 330 people had been given ChAdOx1 based-vaccines for diseases ranging from flu to Zika virus, and prostate cancer to the tropical disease chikungunya.

The virus from chimps is genetically modified so it cannot cause an infection in people. It can then be modified again to contain the genetic blueprints for whatever you want to train the immune system to attack.

15.12.2020 - 10:12 [ BMJ ]

Peter Doshi: Pfizer and Moderna’s “95% effective” vaccines—let’s be cautious and first see the full data

(26.11.2020)

Let’s put this in perspective. First, a relative risk reduction is being reported, not absolute risk reduction, which appears to be less than 1%. Second, these results refer to the trials’ primary endpoint of covid-19 of essentially any severity, and importantly not the vaccine’s ability to save lives, nor the ability to prevent infection, nor the efficacy in important subgroups (e.g. frail elderly). Those still remain unknown.

15.12.2020 - 09:58 [ theHill.com ]

What is sterilizing immunity and do we need it for the coronavirus?

(08.06.2020)

Neutralizing antibodies prevent the virus from replicating.

15.12.2020 - 09:38 [ Bloomberg ]

How a Covid-19 Vaccine Could End Up Helping the Virus Spread

(11.11.2020)

A vaccine that protects against symptoms of Covid-19 could contribute to the spread of the disease if — and this is still just an if — the people who get vaccinated remain capable of carrying and transmitting the virus. That’s a risk that’s gotten little attention amid the deserved jubilation over a Nov. 9 report from Pfizer Inc. and BioNTech SE that their vaccine candidate appears to be highly effective.

08.12.2020 - 18:13 [ University of Oxford ]

First peer-reviewed results of phase 3 human trials of Oxford coronavirus vaccine demonstrate efficacy

. These data indicate that the low dose / standard dose vaccine may provide a protection against asymptomatic infection, but stress that these data are at an early phase, with too high a level of uncertainty to be certain that this vaccine will protect against asymptomatic infection.

08.12.2020 - 18:12 [ theLancet.com ]

Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

ChAdOx1 nCoV-19 appears to be better tolerated in older adults than in younger adults and has similar immunogenicity across all age groups after a boost dose.

08.12.2020 - 18:11 [ DailyMail.co.uk ]

Oxford confirms its Covid vaccine is 70% effective and safe – but scientists warn regulators face ‚dilemma‘ in approving jab to be given as 1.5 doses (which they accidentally found is 90% protective)

The MHRA has been considering whether to approve the vaccine since November 27 and is expected to reach a decision before the end of the year.

06.12.2020 - 15:48 [ Kulvinder Kaur MD, Physician / Twitter ]

There’s NO evidence that Covid candidate vaccines prevent infection, prevent/reduce transmission, reduce hosps or reduce mortality. Nor are clinical trials designed to determine these endpoints. Longterm efficacy/safety also unknowns All we know—may reduce “common cold symptoms”

06.12.2020 - 15:45 [ BMJ ]

Peter Doshi: Pfizer and Moderna’s “95% effective” vaccines—let’s be cautious and first see the full data

(26.11.2020)

Let’s put this in perspective. First, a relative risk reduction is being reported, not absolute risk reduction, which appears to be less than 1%. Second, these results refer to the trials’ primary endpoint of covid-19 of essentially any severity, and importantly not the vaccine’s ability to save lives, nor the ability to prevent infection, nor the efficacy in important subgroups (e.g. frail elderly). Those still remain unknown. Third, these results reflect a time point relatively soon after vaccination, and we know nothing about vaccine performance at 3, 6, or 12 months, so cannot compare these efficacy numbers against other vaccines like influenza vaccines (which are judged over a season). Fourth, children, adolescents, and immunocompromised individuals were largely excluded from the trials, so we still lack any data on these important populations.

I previously argued that the trials are studying the wrong endpoint, and for an urgent need to correct course and study more important endpoints like prevention of severe disease and transmission in high risk people. Yet, despite the existence of regulatory mechanisms for ensuring vaccine access while keeping the authorization bar high (which would allow placebo-controlled trials to continue long enough to answer the important question), it’s hard to avoid the impression that sponsors are claiming victory and wrapping up their trials (Pfizer has already sent trial participants a letter discussing “crossing over” from placebo to vaccine), and the FDA will now be under enormous pressure to rapidly authorize the vaccines.

04.12.2020 - 21:50 [ CNN ]

Vaccination cards will be issued to everyone getting Covid-19 vaccine, health officials say

(02.12.2020)

„Everyone will be issued a written card that they can put in their wallet that will tell them what they had and when their next dose is due,“ Moore said. „Let’s do the simple, easy thing first. Everyone’s going to get that.“

04.12.2020 - 21:47 [ Zero Hedge ]

‚Immunity Cards‘ To Be Issued To All Americans; Enable CDC To Track COVID-19 Vaxx Status In Database

On Wednesday the Department of Defense released the first images of a COVID-19 vaccination record card as well as vaccination kits, according to CNN.

„Everyone will be issued a written card that they can put in their wallet that will tell them what they had and when their next dose is due,“ says Dr. Kelly Moore, associate director of the Immunization Action Coalition.

04.12.2020 - 21:24 [ DailyMail.co.uk ]

No10 stops short of ruling out Covid ‚immunity passports‘ despite saying it is ’not something the PM wants‘ – as Wales raises fears of spot checks at pubs and shops by bringing in ID-style cards for people who get vaccine

– Pfizer vaccines licensed by UK regulator and will be distributed from next week
– Wales says people will be issued with ID-style cards to show they have had jab
– Fears that pubs and shops could demand proof of vaccine before allowing entry

04.12.2020 - 20:50 [ InfectiousDiseaseAdvisor.com ]

Challenges in Assessing the Efficacy of COVID-19 Vaccines

Determining whether a vaccine can protect against severe disease and death from COVID-19 may not be possible in phase 3 clinical trials and will often require long-term, ongoing studies after widespread deployment of a vaccine.

To ensure ongoing evaluation of vaccine safety, well-supported pharmacovigilance studies after licensure will be necessary.

04.12.2020 - 20:47 [ theHill.com ]

Pfizer chairman: We’re not sure if someone can transmit virus after vaccination

Pfizer chairman Albert Bourla told Dateline host Lester Holt that the pharmaceutical company was “not certain” if the vaccine prevented the coronavirus from being transmitted, saying, “This is something that needs to be examined.”

04.12.2020 - 20:15 [ ORF.at ]

WHO: Impfungen allein reichen nicht

„Die Impfungen alleine werden den Job nicht machen“, sagte WHO-Experte Mike Ryan heute in Genf. Sie seien zweifelsfrei ein mächtiges und wirkungsvolles Werkzeug. Aber viele bisherige Hygieneregeln wie soziale Distanz, das Tragen von Masken und häufiges Händewaschen müssten zunächst weiterhin beachtet werden.

04.12.2020 - 16:00 [ Radio Utopie ]

Warum der Pfizer / BioNTech „Impfstoff“ ein gigantischer Betrug und zudem gefährlich ist

1. Dieser sogenannte „Impfstoff“ schützt weder vor Infektion von SARS II (dem aktuellen Coronavirus), noch vor dessen Verbreitung. Er schützt, heisst es, lediglich vor der Krankheit Covid-19. Und das auch nur ca. 3 Monate. Es können allerdings trotzdem „Symptome“ wie Müdigkeit auftreten. Eine Immunität gegen SARS II gibt es durch diesen Impfstoff nicht.

Über diese Informationen herrscht weltweit faktisch Nachrichtensperre.

27.10.2020 - 17:15 [ Heise.de ]

Schwedens beneidenswerte Lage im Anti-Corona-Kampf

Auch ist zu berücksichtigen, dass die Sterbefälle in Schweden dem langjährigen Durchschnitt entsprechen. Während der ersten 35 Wochen dieses Jahres gab es 620 Tote auf 100.000 Einwohner, womit die Zahlen der vorhergehenden Dekade fünfmal über- und fünfmal unterschritten wurden. Der höchste Wert wurde für 2012 mit 650 ermittelt, was ca. 3000 Todesfälle mehr als in diesem Jahr bedeutet. Damals grassierte eine schwere Influenza-Epidemie, die augenscheinlich mehr Opfer forderte als gegenwärtig das Sars-CoV-2-Virus.

14.10.2020 - 20:04 [ Radio Utopie ]

Wie mit dem Ausnahmezustand umgehen? Unterschreibt die Great Barrington Erklärung!

Die Mediziner Dr. Martin Kulldorff, Dr. Sunetra Gupta und Dr. Jay Bhattacharya haben eine logische und praktikable Lösung im Umgang mit SARS II (coronavirus / SARS-CoV-2) und der Krankheit COVID-19 vorgestellt. Statt dem derzeitigen weltweit fast einheitlich ausgerufenen Ausnahmezustand („lockdown“) und faktischen Staatsstreich gegen die (soweit vorhandenen) Verfassungs- und Menschenrechte schlagen sie das Konzept der Herdenimmunität vor.

14.10.2020 - 19:36 [ gbdeclaration.org ]

The Great Barrington Declaration

Those who are not vulnerable should immediately be allowed to resume life as normal. Simple hygiene measures, such as hand washing and staying home when sick should be practiced by everyone to reduce the herd immunity threshold. Schools and universities should be open for in-person teaching. Extracurricular activities, such as sports, should be resumed. Young low-risk adults should work normally, rather than from home. Restaurants and other businesses should open. Arts, music, sport and other cultural activities should resume. People who are more at risk may participate if they wish, while society as a whole enjoys the protection conferred upon the vulnerable by those who have built up herd immunity.

On October 4, 2020, this declaration was authored and signed in Great Barrington, United States, by:

Dr. Martin Kulldorff, professor of medicine at Harvard University, a biostatistician, and epidemiologist with expertise in detecting and monitoring infectious disease outbreaks and vaccine safety evaluations.

Dr. Sunetra Gupta, professor at Oxford University, an epidemiologist with expertise in immunology, vaccine development, and mathematical modeling of infectious diseases.

Dr. Jay Bhattacharya, professor at Stanford University Medical School, a physician, epidemiologist, health economist, and public health policy expert focusing on infectious diseases and vulnerable populations.

14.10.2020 - 19:07 [ gbdeclaration.org ]

Die Great Barrington Erklärung

Diejenigen, die nicht schutzbedürftig sind, sollten sofort wieder ein normales Leben führen dürfen. Einfache Hygienemaßnahmen wie Händewaschen und der Aufenthalt zu Hause im Krankheitsfall sollten von allen praktiziert werden, um den Schwellenwert für die Herdenimmunität zu senken. Schulen und Universitäten sollten für den Präsenzunterricht geöffnet sein. Außerschulische Aktivitäten, wie z. B. Sport, sollten wieder aufgenommen werden. Junge Erwachsene mit geringem Risiko sollten normal und nicht von zu Hause aus arbeiten. Restaurants und andere Geschäfte sollten öffnen können. Kunst, Musik, Sport und andere kulturelle Aktivitäten sollten wieder aufgenommen werden. Menschen, die stärker gefährdet sind, können teilnehmen, wenn sie dies wünschen, während die Gesellschaft als Ganzes den Schutz genießt, der den Schwachen durch diejenigen gewährt wird, die Herdenimmunität aufgebaut haben.

Am 4. Oktober 2020 wurde diese Erklärung in Great Barrington, USA, verfasst und unterzeichnet von:

Dr. Martin Kulldorff, professor of medicine at Harvard University, a biostatistician, and epidemiologist with expertise in detecting and monitoring of infectious disease outbreaks and vaccine safety evaluations.

Dr. Sunetra Gupta, professor at Oxford University, an epidemiologist with expertise in immunology, vaccine development, and mathematical modeling of infectious diseases.

Dr. Jay Bhattacharya, professor at Stanford University Medical School, a physician, epidemiologist, health economist, and public health policy expert focusing on infectious diseases and vulnerable populations.

14.10.2020 - 19:05 [ ZDF ]

Umstrittene Barrington-Erklärung – Herdenimmunität statt Corona-Lockdown?

Ihre Idee: Sie wollen auf Herdenimmunität setzen. Herdenimmunität bedeutet, dass genügend Menschen in der Bevölkerung immun gegen das Virus sind und es so nicht mehr weitergegeben wird. Herdenimmunität kann theoretisch auf zwei Wegen erreicht werden: mit einem Impfstoff oder über natürliche Ansteckungen. Auf letzteres setzt die Barrington-Erklärung.

07.10.2020 - 12:27 [ BBC ]

Genome editing wins Nobel chemistry prize

Her work showed that tracrRNA is part of the organism’s immune defences.

This system, known as CRISPR/Cas, disarms viruses by cleaving their DNA.

In 2011, the same year she published this work, Charpentier began a collaboration with Doudna to recreate the bacterium’s genetic scissors in a test tube. They also worked on simplifying the scissors‘ molecular components so they were easier to use.

12.05.2020 - 20:34 [ Robert F. Kennedy, Jr. / Children’s Health Defense ]

Flu Misinformation and Coronavirus Fears: My Letter to Dr. Sanjay Gupta

9. CNN assertion: Sanjay, I’ve watched your video assuring the public that getting the flu shot cannot increase one’s chances of getting the flu.

Fact: While that assertion has some meager support from a very small number of studies, the overwhelming weight of published science suggests that getting an annual flu shot can actually increase your risk of both flu and flu-like illnesses.

Only about 7 percent to 15 percent of what are called “influenza-like illnesses” are actually caused by influenza viruses. Many studies suggest the flu vaccine increases vulnerability to both flu infections and the remaining 85% -93% of non-flu respiratory infections.

A 2011 study of healthy Australian children published in the Pediatric Infectious Disease Journal found that seasonal flu shots increase the risk of flu by 73% and doubled the risk of non-flu respiratory infections.

Similarly, another 2012 randomized controlled trial published in Clinical Infectious Diseases found that influenza-vaccinated children had no significantly lessened risk from influenza and also a higher risk of infection from non-influenza viruses.

Furthermore, the flu vaccine depletes capacity to fight off future flu infections. In April 2010, a study (by Skowronek, et al) published in the journal PLoS Medicine reported the “unexpected” finding from four epidemiologic studies in Canada that receipt of the influenza vaccine for the 2008 – 2009 season, while apparently effective in reducing the risk of illness due to the seasonal flu, was associated with an increased risk of illness due to the pandemic influenza A (H1N1) “swine flu” virus during the spring and summer of 2009. The scientists suggested that this finding could be due to the difference in the way the vaccine affects the immune system compared with natural infection.

02.05.2020 - 19:48 [ Nature.com ]

Antibody responses to SARS-CoV-2 in patients with COVID-19

(29.04.2020)

We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG).

02.05.2020 - 19:45 [ Ansa.it ]

All those infected develop antibodies says study in Nature

All the people who recover from COVID-19 develop antibodies, according to a study by Chongqing Medical University published in the Nature Medicine journal.
100% of the Infected Have Antibodies.
The study revealed that 100% of the patients analysed had IgG antibodies, the ones produced during the first infection and which give long-term protection.

24.04.2020 - 16:59 [ QuickTake by Bloomberg ]

“It’s much more sustainable.” Sweden has left its schools, gyms, cafes, bars and restaurants open throughout the spread of the #coronavirus pandemic. Anders Tegnell, the man behind this strategy, now says the country may be over the worst

24.04.2020 - 16:53 [ Nature.com ]

‘Closing borders is ridiculous’: the epidemiologist behind Sweden’s controversial coronavirus strategy

What would you have done differently?

We underestimated the issues at care homes, and how the measures would be applied. We should have controlled this more thoroughly. By contrast, the health system, which is under unusual pressure, has nevertheless always been ahead of the curve.

Are you satisfied with the strategy?

Yes! We know that COVID-19 is extremely dangerous for very old people, which is of course bad. But looking at pandemics, there are much worse scenarios than this one. Most problems that we have right now are not because of the disease, but because of the measures that in some environments have not been applied properly: the deaths among older people is a huge problem and we are fighting hard.

24.04.2020 - 13:26 [ Daily Mail ]

Sweden’s chief epidemiologist says lockdowns may not save lives because 50% of their deaths are in care homes – and they’ll handle second wave better because they now have higher levels of immunity

A lockdown might not have saved lives in Sweden because half its coronavirus deaths are in care homes where visits are already banned, the country’s top disease expert said today.

State epidemiologist Anders Tegnell said it was ‚hard to understand‘ how a full-scale lockdown would have stopped the virus spreading into nursing homes.

While Sweden has avoided introducing a lockdown, it has banned visitors from care homes in one of its few restrictive measures, with schools, bars, shops and restaurants still open.

23.04.2020 - 19:15 [ CBS News ]

Study shows 13.9% of people tested in New York have coronavirus antibodies, Cuomo says

That suggests that 2.7 million people have been infected statewide.

The survey was taken from a sample size of about 3,000 people found outside their homes, shopping at essential businesses, such as grocery stores, which remain open.

11.04.2020 - 18:51 [ DailyMail.co.uk ]

Scientists say many more people than previously thought could have acquired coronavirus immunity after discovering 15% of people in city dubbed ‚German Wuhan‘ could be carrying antibodies

An immunity rate of 15 per cent is already enough to slow the spread of the virus significantly, they added.

However, they admitted that all governments need to collect more data as the world still doesn’t know enough about the virus.

Last week, research conducted by Prof Streeck showed that the home of one infected family did not have ‚any live virus on any surface‘, adding even more questions as to how the virus is spread from person to person.

Prof Streeck said the virus had not even been found on door knobs or animal fur.

11.04.2020 - 18:45 [ humanrightsinvestigations.files.wordpress.com ]

Vorläufiges Ergebnis und Schlussfolgerungen der COVID-19 Case-Cluster-Study (Gemeinde Gangelt)

Vorläufiges Ergebnis: Es wurde eine bestehende Immunität von ca.14% (anti-SARS-CoV2 IgG positiv, Spezifität der Methode >,99 %) festgestellt. Etwa 2% der Personen wiesen eine mittels PCR Methode festgestellte aktuelle SARS-CoV-2 Infektion auf. Die Infektionsrate (aktuelle Infektion oder bereits durchgemacht) betrug insgesamt ca. 15%. Die Letalität (case fatality rate) bezogen auf die Gesamtzahl der Infizierten in der Gemeinde Gangelt beträgt mit den vorläufigen Daten aus dieser Studie ca. 0,37%. Die in Deutschland derzeit von der Johns-Hopkins University berechnete Letalität beträgt 1,98 % und liegt damit um das 5-fache höher. Die Mortalität bezogen aufdie Gesamtpopulation in Gangelt beträgt derzeit 0,15%.

11.04.2020 - 18:39 [ bernie / Twitter ]

DIESE STUDIE WURDE V. SERVER D. STAATSKANZLEI NRW GELÖSCHT?

Vorläufiges Ergebnis und Schlussfolgerungen der COVID-19 Case-Cluster- Study (Gemeinde Gangelt) Prof.Dr.Hendrik Streeck Prof.Dr.Gunther Hartmann Prof.Dr.Martin Exner Prof.Dr.Matthias Schmid

10.04.2020 - 10:44 [ theHill.com ]

Fauci: Recovered coronavirus patients will likely be immune if second wave hits in fall

While speaking with Journal of the American Medical Association editor Howard Bauchner Wednesday, Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID), said that because the virus doesn’t seem to be mutating much, it’s unlikely people will test positive a second time.

“Generally we know with infections like this, that at least for a reasonable period of time, you’re going to have antibodies that are going to be protective,” Fauci said.

10.04.2020 - 10:36 [ ZDF ]

Markus Lanz vom 9. April 2020

Zu Gast: Virologe Prof. Hendrik Streeck, Wissenschaftsjournalist Dirk Steffens, Pathologe Prof. Klaus Püschel, Unternehmer Martin Kind und Journalistin Annette Hilsenbeck

10.04.2020 - 10:24 [ Die Rote Fahne / Twitter ]

Gut zu wissen, dass Teile der deutschen Wissenschaft noch arbeiten. Prof. Dr. Hendrik Streeck: Die Mortalität des Virus unter der Gesamtbevölkerung beträgt 0,06 Prozent.

(…)

10.04.2020 - 09:50 [ Bayrischer Rundfunk ]

Virologe Streeck: Immunität bedeutet langsamere Ausbreitung der Epidemie

In dieser Folge spricht Virologe Hendrik Streeck vom Uniklinikum Bonn mit der Wissenschaftsredakteurin Jeanne Turczynski darüber, warum die Immunität in Gangelt höher ist als im Rest des Landes, was man von Heinsberg lernen und kann und warum die Ausgangsbeschränkungen in vier Phasen gelockert werden könnten.

10.04.2020 - 09:46 [ Dwarslooper / Twitter ]

Annahme, dass Immunität nach #Corona Infektion 6-8 Monate anhält. Heinsberg-Studie vorgestellt: Streeck: Beginn von Corona-Lockerungen möglich

09.04.2020 - 17:59 [ Hendrik Streeck, Direktor des Instituts für Virologie und HIV-Forschung an der Medizinischen Fakultät der Universität Bonn / Twitter ]

Kurzer Blick hinter die Kulissen. Unser Team, das die Studie verantwortet und ermöglicht hat. Prof. Dr. Martin Exner, Prof. Dr. Gunther Hartmann,

09.04.2020 - 17:44 [ banejii / Twitter ]

Sterblichkeit viel geringer. Heinsberg-Studie enträtselt Coronavirus.

09.04.2020 - 17:37 [ ZDF heute ]

Im Kreis #Heinsberg (NRW) war das erste #Coronavirus-Epizentrum in Deutschland. Dort wir der Ausbruch nun wissenschaftlich untersucht.

#Gangelt @hendrikstreeck
@UniBonn