Archiv: RaBtCoV/4991 / RaTG13 / btCoV-4991 (renamed coronavirus discovered in 2013)


20.02.2021 - 04:50 [ researchgate.net ]

Studie zum Ursprung der Coronavirus-Pandemie

Zusammenfassend kann festgehalten werden, dass es sehr viele Indizien gibt, die einen Laborunfall im „Wuhan Institute of Virology“ als die mit Abstand wahrscheinlichste Ursache für die Corona-Pandemie erscheinen lassen. In diesem Fall würde es sich nicht um eine „Naturkatastrophe“ handeln, sondern um eine von Menschen selbst herbeigeführte Tragödie. Es besteht eine sehr große Gefahr darin, die Frage nach der Ursache für die gegenwärtige Pandemie „als geklärt“ zu deklarieren, wie etwa in dem Statement [III.4] einiger Virologen. Für politische Entscheidungsträger macht es unbestreitbar einen Unterschied, ob sie Wildtiermärkte oder Hochrisikoforschung mit gentechnisch manipulierten Viren weltweit verbieten sollen. Diese Frage muss verstärkt in den Vordergrund rücken, ansonsten könnten Corona- und andere Virenarten noch ein viel größeres Gefahrenpotential entwickeln, nicht nur in der Gegenwart, sondern auch in der Zukunft.

(…)

Auffallend bei der gegenwärtigen Pandemie im Vergleich zu früheren Ausbrüchen von Coronavirus-bedingten Erkrankungen ist:
1) Wir haben es in der gegenwärtigen Pandemie mit einem Erreger zu tun, der mit einer bislang nicht bekannten Effizienz menschliche Zellen angreift.
2) Dabei werden nicht nur die (oberen) Atemwege, sondern auch innere Organe angegriffen und in ihrer Funktion teilweise schwer geschädigt.
Man muss sich daher notwendigerweise die Frage stellen, wie eine solche nahezu perfekte Adaption von Coronaviren an menschliche Zellrezeptoren zustande kommen konnte, um zukünftige Pandemie-Gefahrenpotentiale identifizieren zu können.

20.02.2021 - 04:28 [ Tagesschau.de ]

Dokumentation zu Virusherkunft: Kaum Belege für Labortheorie

Der Professor scheint seit Langem kursierende Vermutungen wissenschaftlich zu bestätigen. Doch nicht das Ergebnis steht nun im Mittelpunkt, stattdessen löste die Pressemitteilung eine Debatte über die Qualität seiner Arbeit aus. So distanzierten sich Studierende der Universität Hamburg und der Studierendenausschuss von der Veröffentlichung. Sie entspreche nicht den wissenschaftlichen Standards, die von einer Universität erwartet würden.

16.02.2021 - 09:39 [ Peter Ben Embarek / Twitter ]

Thanks @kakape for the opportunity to clarify our findings. One of the misunderstanding has been about the nature of our work in the past month. It was a joint @WHO – #China mission to review the July agreed phase 1 studies and plan a series of new studies. Work in progress.

16.02.2021 - 09:37 [ Peter Daszak / Twitter ]

This was NOT my experience on @WHO mission. As lead of animal/environment working group I found trust & openness w/ my China counterparts. We DID get access to critical new data throughout. We DID increase our understanding of likely spillover pathways.

(13.02.2021)

16.02.2021 - 09:34 [ Tagesschau.de ]

WHO-Experten fordern mehr Daten von China

Aus chinesischer Sicht war es gut gelaufen: Bei der Abschlusspressekonferenz der WHO-Mission vergangene Woche in Wuhan gab es keine Kritik an China. Allerdings auch keine wirklich dramatisch neuen Erkenntnisse über den Ursprung der Pandemie. Jetzt aber kommen aus dem Kreis der WHO-Experten Forderungen nach Zugang zu mehr chinesischen Daten, um die Spur der Pandemie weiter zurückverfolgen zu können.

09.02.2021 - 12:00 [ World Health Organization (WHO) / Twitter ]

LIVE from Wuhan : Media briefing on #COVID19 origin mission

09.02.2021 - 11:53 [ ORF.at ]

WHO: Ursache für Ausbruch in Wuhan noch nicht geklärt

Die Forschung müsse sich aber darauf konzentrieren, wie das Virus in Tieren zirkuliert, bevor Menschen infiziert werden, sagte der Experte. Ein Virus, das eine Pandemie auslösen kann, müsse bereits an den menschlichen Kontakt angepasst sein, sagte Liang.

08.02.2021 - 16:35 [ Telegraph.co.uk ]

Did the Covid-19 virus really escape from a Wuhan lab?

Chan and her colleague Dr Shing Hei Zhan scrutinised the evolutions of SARS-CoV-1 (the cause of the 2003 SARS epidemic) and SARS-CoV-2 (the cause of the current pandemic) in the early months of their respective outbreaks and found that while the former mutated rapidly in early human cases, as the virus adapted to its new host, the latter did not. This implies that the virus causing Covid-19 was already well adapted to infecting human beings, a point that was also suggested by the World Health Organization in its global study on the origins of Covid-19, published in November.

There are three possible explanations for this. The first is that the virus had circulated, undetected, in people for months. The second is that the virus was already highly adept at human-to-human transmission, even while it was still in bats or other animals. The third is that it had become adapted in human cells, or humanised animals, in a laboratory.

16.01.2021 - 13:04 [ MSN.com ]

Coronavirus D614G mutation found in 99.9% of cases at US hospital

(02.11.2020)

The finding adds credence to the theory the mutation, which accounts for 85 per cent of global cases, is more contagious than the original strain.

D614G is by far the most common strain of coronavirus affecting humans worldwide and first appeared in February in Europe.

16.01.2021 - 13:04 [ Wall Street Journal ]

The World Needs a Real Investigation Into the Origins of Covid-19

The world needs an inquiry that considers not just natural origins but the possibility that SARS-CoV-2, the virus that causes Covid-19, escaped from a laboratory. The WHO team, however, plans to build on reports by Chinese scientists rather than mount an independent investigation. Given that Chinese authorities have been slow to release information, penalized scientists and doctors who shared clinical and genomic details of the novel coronavirus, and have since demonstrated a keen interest in controlling the narrative of how the virus emerged, this is not a promising foundation for WHO’s investigation.

15.01.2021 - 04:55 [ sun-sentinel.com ]

World Health Organization team arrives in Wuhan to investigate coronavirus pandemic’s origins

They will undergo a two-week quarantine as well as a throat swab test and an antibody test for COVID-19, according to CGTN, the English-language channel of state broadcaster CCTV. They are to start working with Chinese experts via video conference while in quarantine.

The team includes virus and other experts from the United States, Australia, Germany, Japan, Britain, Russia, the Netherlands, Qatar and Vietnam.

14.01.2021 - 13:10 [ New York Times ]

Two Members of W.H.O. Team on Trail of Virus Are Denied Entry to China

But in a sign of Beijing’s continuing efforts to control the investigation, the team of scientists and W.H.O. employees almost immediately ran into obstacles. Two scientists were unable to enter China at the last minute and remained in Singapore because they tested positive for coronavirus antibodies, the W.H.O. said in a Twitter post. The Chinese authorities required the remaining 13 experts to undergo two weeks of quarantine in Wuhan, where the virus first emerged in late 2019.

11.01.2021 - 20:39 [ University of Cambridge / Phys.org ]

Study identifies genetic changes likely to have enabled SARS-CoV-2 to jump from bats to humans

A new study, involving the University of Cambridge and led by the Pirbright Institute, has identified key genetic changes in SARS-CoV-2—the virus that causes COVID-19—that may be responsible for the jump from bats to humans, and established which animals have cellular receptors that allow the virus to enter their cells most effectively.

The genetic adaptions identified were similar to those made by SARS-CoV—which caused the 2002-2003 SARS epidemic—when it adapted from bats to infect humans.

11.01.2021 - 12:00 [ cgtn.com ]

WHO experts to visit China on January 14 for virus origins probe

„After consultation between the two sides, the WHO international experts team on the traceability of the novel coronavirus will visit China on January 14 to conduct joint scientific cooperation with Chinese scientists,“ according to a statement published on the NHC website on Monday.

The commission did not provide further details on the scientists‘ itinerary.

11.01.2021 - 12:00 [ ORF.at ]

China erlaubt WHO-Experten Einreise am 14. Jänner

Die Delegation soll nun am 14. Jänner eintreffen, teilte die Nationale Gesundheitsbehörde in Peking mit, ohne weitere Einzelheiten zu nennen.

06.01.2021 - 05:53 [ theGuardian.com ]

China blocks entry to WHO team studying Covid’s origins

The WHO has been attempting to send in the team of global experts from a number of countries for some months. It has been talking with Chinese officials since July. Scientists have long said it is essential to find out how the virus jumped species into humans.

06.01.2021 - 05:38 [ ORF.at ]

China blockierte WHO-Experten in letzter Minute

Das genaue Datum und die Details der Mission hat die WHO bis zuletzt geheim gehalten. Das zehnköpfige internationale Team sollte Anfang Jänner nach China aufbrechen und sich dort für fünf bis sechs Wochen aufhalten. Die Mission gilt als politisch äußerst heikel. Die Regierungen mehrerer Länder werfen den chinesischen Behörden Vertuschungsversuche am Anfang der Pandemie vor.

04.01.2021 - 11:08 [ Rubikon ]

Die Vertuschungsaktion

(22.12.2020)

Laut Alina Chan, Molekularbiologin am Broad Institute of Harvard und am MIT, kann man die Evolution von SARS-CoV-2 nicht mit der These eines zoonotischen Ursprungs in Einklang bringen, denn das Virus war bereits vollständig für die Mensch-zu-Mensch-Übertragung angepasst, als es zum ersten Mal auftrat.

Die renommierte medizinische Fachzeitschrift „Nature“ erlaubte anscheinend einigen Autoren, ihre Daten heimlich zu ändern, ohne auf diese Korrekturen in den Artikeln hinzuweisen.

Chans Untersuchungen zeigen, dass die Autoren ihre Proben umbenannt, falsch zugeordnet und ein Genomprofil generiert haben, das mit keiner ihrer Proben übereinstimmt. In anderen Papers fehlen Daten.

Das Coronavirus RaTG13, zu 96 Prozent mit SARS-CoV-2 identisch und somit der engste Verwandte, ist in Wirklichkeit btCoV-4991. Dieses Genom wurde schon 2013 in Proben nachgewiesen und 2016 veröffentlicht.

03.01.2021 - 18:22 [ theAustralian.com.au ]

Coronavirus: Scientists cast doubt on WHO’S China mission to find COVID-19 origin in Wuhan

(today)

Daszak was a frequent traveller to Wuhan and the bat colonies of Yunnan with WIV scientists on projects funded by EcoHealth with US grants — until the Trump administration abruptly severed support, citing bio-security concerns.

The British scientist has forcefully dismissed the scenario of a laboratory leak as “baloney” and a “conspiracy theory”, and praised the work of his Chinese counterparts, notably Shi Zhengli, the “bat woman” of Wuhan, who traced the origins of the earlier Sars coronavirus outbreak to a colony of horseshoe bats in Yunnan.

03.01.2021 - 18:16 [ DailyMail.co.uk ]

The world must investigate all the mounting evidence Covid leaked from a Wuhan lab, writes IAN BIRRELL

(2 January 2021 | Updated: 12:06 GMT, 3 January 2021)

Now there is growing clamour from experts around the world that no stone should be left unturned during this inquiry – and that it must include one key element of a hunt which has all the hallmarks of a thriller novel.

This centres on a cave filled with bats, a clutch of mysterious deaths, some brilliant scientists carrying out futuristic experiments in a secretive laboratory – and a cover-up of epic proportions that, if proven, would have huge consequences for the Chinese Communist Party and the global practice of science.

03.01.2021 - 18:07 [ ChildrensHealthDefense.org ]

Did Top Medical Journal Help Cover Up Origins of SARS-CoV-2?

(11.09.2020)

– According to Alina Chan, a molecular biologist at the Broad Institute of Harvard and MIT, SARS-CoV-2 did not evolve in a manner you’d expect, had it jumped from an animal to a human. It sprang into action fully evolved for human transmission
– It appears Nature, a top medical journal, has allowed authors to secretly alter data sets in their papers without publishing notices of correction
– Chan’s investigation reveals authors have renamed samples, failed to attribute them properly, and produced a genomic profile that doesn’t match the samples in their paper. Others are missing data
– RaTG13 — the coronavirus that most resembles SARS-CoV-2, being 96% identical — is actually btCoV-4991, a virus found in samples collected in 2013 and published in 2016
– If SARS-CoV-2, the virus responsible for COVID-19 and the subsequent response to it, came from a lab, then we need to reassess the future of gain-of-function research that allows for the weaponization of viruses

03.01.2021 - 17:53 [ Alina Chan / Twitter / threadreaderapp.com ]

Get ready. This is going to be an important thread. Election season will be over soon and hopefully more people will devote some attention to this… I’m going to walk through a timeline of SARS2-related virus data published in the months after the outbreak. (1/30)

(25 Oct 20)

Since the outbreak in late 2019, events have been unfolding at such a fast pace that it is difficult to keep track of what happened and in what order.

I use visualizations of the timeline to follow key events relating to the search for the animal host of SARS2. (2/30)

Even today, I still hear people saying that SARS-CoV-2 came from pangolins and a Seafood market in Wuhan. I hope this analysis will help to clear things up. It will refresh us on significant early pandemic events and major publications discussing the origins of the virus (3/30).

03.01.2021 - 17:36 [ Annette Gartland / changingtimes.media ]

SARS-CoV-2: lab-origin hypothesis gains traction

(October 12, 2020)

– Researchers say there’s evidence within the SARS-CoV-2 spike protein that suggests the virus is a product of genetic manipulation.
– Exiled Chinese scientist Li-Meng Yan says SARS-CoV-2 is an “unrestricted bioweapon” and there’s been “large-scale, organised scientific fraud”.
– Six miners in Yunnan, who were removing bat faeces from a cave, suffered a severe pneumonia-like illness in 2012 and three of them died. They had a high fever, dry cough, sore limbs, and headaches – all symptoms associated with Covid-19.
– A database containing information about the sequencing of samples collected from the Yunnan mine by researchers from the Wuhan Institute of Virology has been taken offline.
– There are said to be sequences of HIV-1 in the SARS-CoV-2 genome.
American and Chinese scientists have collaborated for decades on gain-of-function research.
– There have been numerous ‘leaks’ of viruses from laboratories, including during the SARS outbreak in 2003–2004.

03.01.2021 - 17:07 [ The Australian / ecambiomed.com ]

THE AUSTRALIAN | RaBtCoV/4991 | Out of the bat cave: China’s deadly maze Deep in China, three men entered a cave and died with a mystery illness. Why was it kept under wraps for years?

(July 6th, 2020)

Ebright believes an even more controversial theory should not be ruled out. “It also, of course, is a distinct possibility that work done in the laboratory on RaTG13 may have resulted in artificial in-laboratory adaptation that erased those three to five decades of evolutionary distance.”

It is a view Hibberd does not believe is possible. “Sars-Cov-2 and RaTG13 are not the same virus and I don’t think you can easily manipulate one into the other. It seems exceptionally difficult.”

Ebright alleges, however, that the type of work required to create COVID-19 from RaTG13 was “identical” to work the laboratory had done in the past. “The very same techniques, the very same experimental strategies using RaTG13 as the starting point, would yield a virus essentially identical to Sars-Cov-2.”

03.01.2021 - 16:55 [ Dr. Jurgen Mayer / Peakprosperity.com ]

Scientific history of RaTG13

(Jul 07, 2020)

In early February 2019, Dr. Shi’s team suddenly tossed a brand new genome online and published a paper, citing that hCoV-2019 must come from (horseshoe) Bats because it is so similar to this other sample obtained from Bats in July 2013.

*If an existing genome was already in the system and the new data was uploaded we would expect to see reference notes and that the previous listing had been removed or updated.

*The scientists were forcing an argument that this newly published genome (RaTG13) came from a Bat and is the closest relative to hCoV-2019, therefore our pandemic virus more than likely came from a bat.

At the time of this publication, there is quite literally zero record or publication referencing this sudden new virus that they designated as Bat SL-CoV RaTG13 (Ra being Rhinolophus affinis, 13 being sampling year). How could this new virus have been just ABSENT from the scientific community for SEVEN YEARS?!

In fact, there are (comparatively) barely any Rhinolophus Affinis Samples in our databases. Meaning there is a small pool or Bat viruses from this specific species. The team simply renamed the sample and maybe forgot that 4991 was already in GenBank?! Because 4991 is actually RaTG13, yet this super important publication which was read by all of the top scientists in the world makes zero mention of this important fact.

03.01.2021 - 16:33 [ Shing Hei Zhan, Benjamin E. Deverman, Yujia Alina Chan / bioRxiv.org ]

SARS-CoV-2 is well adapted for humans. What does this mean for re-emergence?

(May 02, 2020)

Abstract: In a side-by-side comparison of evolutionary dynamics between the 2019/2020 SARS-CoV-2 and the 2003 SARS-CoV, we were surprised to find that SARS-CoV-2 resembles SARS-CoV in the late phase of the 2003 epidemic after SARS-CoV had developed several advantageous adaptations for human transmission. Our observations suggest that by the time SARS-CoV-2 was first detected in late 2019, it was already pre-adapted to human transmission to an extent similar to late epidemic SARS-CoV. However, no precursors or branches of evolution stemming from a less human-adapted SARS-CoV-2-like virus have been detected. The sudden appearance of a highly infectious SARS-CoV-2 presents a major cause for concern that should motivate stronger international efforts to identify the source and prevent near future re-emergence.