First published on April 8, 2020
Timeline from September 2019 – April 2020
First published on April 8, 2020
Timeline from September 2019 – April 2020
Early into the health crisis, Gilead began testing remdesivir as a possible treatment for the illness caused by the novel coronavirus. The antiviral initially had been studied in other coronaviruses — severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). More recently, remdesivir entered clinical trials for COVID-19, and as promising data emerged, the U.S. Food and Drug Administration granted the drug Emergency Use Authorization.
Separately, Gilead also provided updates on its production plans for the drug, noting that it expects to have over two million Remdesivir treatment courses manufactured by the end of 2020, with the number rising further over 2021, as it optimizes the manufacturing process.
For more details on the stock price and fundamental performance of some of the key U.S. listed companies developing coronavirus therapeutics, view our theme of Covid-19 Treatment Stocks.
Getting to that „new normal“ as quickly as possible is the target for governments around the globe, Many find antibody-testing the entire population a tantalising idea where infection rates are high.
In Germany, the country’s disease control and prevention agency, the Robert Koch Institute, is conducting large-scale random antibody testing.
Holmes traded out two stocks a week later, on Jan. 29, then on Feb. 27 made two purchases that could prove advantageous in the weeks ahead: Holmes purchased between $15,001 and $50,000 of stock in each of two more companies, the pharmaceutical company Gilead, Inc. — which makes remdesivir, a drug that is currently being tested to treat coronavirus — and wipe manufacturer Clorox.
(2 May 2009)
Mr Rumsfeld, a former chairman of the company, has refused to comment on whether he still holds shares in Californian firm Gilead Sciences, which developed the drug now being desperately stockpiled by governments around the world to combat the threatened pandemic.
Israel will receive a donation of Remdesivir, an experimental antiviral drug for COVID-19, from its U.S. manufacturer, Israel’s prime minister’s office said on Tuesday.
The Israeli cabinet approved in a telephone vote the decision by the Health Ministry to issue a permit to accept a donation of the drug from Gilead Sciences Inc, the U.S. biopharmaceutical company that produces the drug.
Gilead Sciences Inc has signed agreements with four pharma companies, Dr Reddy’s Laboratories Ltd, Biocon arm Syngene International Ltd, Zydu Cadila Ltd and Egypt-based Eva Pharma Pvt Ltd, for manufacturing and sale of remdesivir, which has shown greater impact during initial two phases of trials. The company had previously signed pacts with five other companies including Cipla, Jubilant Life, Hetero Drugs, Mylon and Pakistan’s Ferozsons Laboratories.
„Based on the analysis and on the review of the published evidence, the executive group of the Solidarity / recovery trial has … after the deliberation … concluded that hydroxychloroquine arm will be stopped from the Solidarity Trial,“ Ana Maria Henao Restrepo, Medical Officer, Department of Immunization Vaccines and Biologicals at WHO said on Wednesday at a press conference in Geneva.
An additional (so-called) benefit of this alternative brand of vaccine technology is that, once developed, it will not require refrigeration. Naturally, this has considerable implications for wide-spread use in third world countries. Unsurprisingly, funding for this emerging variation of vaccine technology is coming from the NIH as well as the Bill and Melinda Gates Foundation.
It goes without saying that pharmaceutical companies have become so infused into our globalized wellness infrastructure to the point that we don’t even see them anymore. They have become pervasively entrenched into the background of our social fabric, and are considered as mundanely-important and essential as the plumbing in our houses and our cities. This widespread habituation has ultimately numbed our sense of collective concern to the point where we aren’t as alarmed by how their products are conceived, nor by who is ultimately funding their research and development.
Dabei werden der Einsatz gefährlicher Pestizide und die Nutzung genmanipulierter Pflanzen in Ländern des globalen Südens gefördert oder die wenig profitable Entwicklung von Impfstoffen mit hohen Summen unterstützt. Kritiker monieren seit Jahren, von der Gates Foundation unterstützte Projekte zielten vor allem darauf ab, quantitativ messbare Erfolge zu erzielen – ohne Rücksicht auf ökologische Erwägungen. Zudem werden zentrale Felder der Politik demokratischer Kontrolle entzogen.
The outbreak has also brought new privacy issues, as companies beef up surveillance with tech like thermal cameras and facial recognition in preparation for when people return to their everyday lives.
Surveillance technology has slowly integrated into our daily lives, with facial recognition getting added as a „convenience“ feature for casinos and ordering food. The coronavirus has sped up that process, in the name of public health.
1. When the individual attempts to gain access to, for instance, a place of work, the business will verify1.the validity of the credential, then make a determination to grant or deny access. This verification does not require contacting the issuer of the credential.
2. As part of the process of determining whether to grant or deny access, the verifier can compare the cryptographically verified photo against the individual through manual means or through automated facial recognition.
JASON HIRSCH, Public Policy Manager,
Jason Hirsch joined Facebook’s Public Policy team in October 2018, where he focuses on development of policies to help guide Facebook’s approach to content distribution and moderation. Within that role, Mr. Hirsch heads up Facebook’s Health Integrity Policy efforts, including leading the development of Facebook’s multi-faceted approach to combatting misinformation about vaccinations.
Examine the feasibility of developing a common vaccination card/passport for EU citizens (that takes into account potentially different national vaccination schedules and), that is compatible with electronic immunisation information systems and recognised for use across borders, without duplicating work at nati
The mayor of Nice has urged French PM Edouard Philippe to introduce new travel controls during the Covid-19 pandemic through “health passports” in the parts of France which border other countries.
Senior members of the Australian intelligence community told The Sydney Morning Herald and The Age a research document shared in political circles under the Five Eyes intelligence arrangement was mostly based on news reports and contained no material from intelligence gathering.
UK officials believe it is not possible to be absolutely sure about the origins but point to scientific opinion suggesting the most likely scenario is …
There is no current evidence to suggest that coronavirus leaked from a Chinese research laboratory, intelligence sources have told the Guardian, contradicting recent White House claims that there is growing proof this is how the pandemic began.
The sources also insisted that a “15-page dossier” highlighted by the Australian Daily Telegraph which accused China of a deadly cover up was not culled from intelligence from the Five Eyes network, an alliance between the UK, US, Australia, New Zealand and Canada.
RADDATZ: Do you believe it was manmade or genetically modified?
POMPEO: Look, the best experts so far seem to think it was manmade. I have no reason to disbelieve that at this point.
RADDATZ: Your — your Office of the DNI says the consensus, the scientific consensus was not manmade or genetically modified.
POMPEO: That’s right. I — I — I agree with that. Yes. I’ve — I’ve seen their analysis. I’ve seen the summary that you saw that was released publicly. I have no reason to doubt that that is accurate at this point.
Speaking on the ABC program “This Week,” Mr. Pompeo, the former C.I.A. chief and one of the senior administration officials who is most hawkish on dealing with China, said that “there’s enormous evidence” that the coronavirus came from the lab, though he agreed with the intelligence assessment that there was no indication that the virus was man-made or genetically modified.
The third source said it is also possible the US is not sharing all of its intelligence. While the overwhelming majority is shared among the Five Eyes members, there are pockets of information that each country keeps to itself.
Australia, the United Kingdom, and Canada have pointedly not backed up America’s apparent surety that the novel coronavirus was either deliberately or accidentally leaked from a Chinese lab. All three countries are members of the Five Eyes, the postwar espionage pact designed to share intelligence between like-minded governments, along with New Zealand.
It can also be revealed the Australian government trained and funded a team of Chinese scientists who belong to a laboratory which went on to genetically modify deadly coronaviruses that could be transmitted from bats to humans and had no cure, and is now the subject of a probe into the origins of COVID-19.
As intelligence agencies investigate whether the virus inadvertently leaked from a Wuhan laboratory, the team and its research led by scientist Shi Zhengli feature in the dossier prepared by Western governments that points to several studies they conducted as areas of concern.
The same Big Pharma actors, the Gates Foundation, Anthony Fauci et al were behind the H1N1 swine flu scam. Members of the Expert committee of the WHO (including Director General Margaret Chan) were bribed in 2009.
The same committee was bribed in January 2020. And a lot of people have been bribed in relation to COVID-19. That’s an understatement.
“The entire Intelligence Community has been consistently providing critical support to U.S. policymakers and those responding to the COVID-19 virus, which originated in China. The Intelligence Community also concurs with the wide scientific consensus that the COVID-19 virus was not manmade or genetically modified.
“As we do in all crises, the Community’s experts respond by surging resources and producing critical intelligence on issues vital to U.S. national security. The IC will continue to rigorously examine emerging information and intelligence to determine whether the outbreak began through contact with infected animals or if it was the result of an accident at a laboratory in Wuhan.”
In an unusual public statement, the Office of the Director of National Intelligence, or ODNI, also said that U.S. intelligence agencies concur with the broad scientific consensus that “the Covid-19 virus was not manmade or genetically modified.”
“It’s far more likely that Mother Nature is just a step ahead of us and has created a novel pathogen, now able to move quite effectively from human to human,” said Jason Rao, a biosecurity specialist, former senior policy adviser to President Barack Obama and executive director of Health Security Partners, a D.C.-based nonprofit organization focused on global biological threat reduction.
Remdesivir use was not associated with a difference in time to clinical improvement (hazard ratio 1·23 [95% CI 0·87–1·75]). Although not statistically significant, patients receiving remdesivir had a numerically faster time to clinical improvement than those receiving placebo among patients with symptom duration of 10 days or less (hazard ratio 1·52 [0·95–2·43]). Adverse events were reported in 102 (66%) of 155 remdesivir recipients versus 50 (64%) of 78 placebo recipients. Remdesivir was stopped early because of adverse events in 18 (12%) patients versus four (5%) patients who stopped placebo early.
As the deaths caused by the coronavirus passed 190,000 at the global level and the number of cases crossed the 2.7 million threshold (Johns Hopkins University data updated Friday), a „historic collaboration“ was launched to accelerate the arrival of a vaccine.
This launch brings together world leaders, the private sector, scientific and humanitarian actors and other partners to promote health, keep the world safe and advance the public good.
Human health is the quintessential global public good.
And today, we face a global public enemy like no other.
Friday’s launch event was co-hosted by French President Emmanuel Macron, European Commission President Ursula von der Leyen and philanthropists Bill and Melinda Gates.
Leaders from South Africa, Rwanda, Germany, Great Britain, Spain, Italy, Malaysia, Saudi Arabia, Finland and Costa Rica joined the call to pledge their commitment to work with and support the ACT Accelerator.
Representatives from the United States and China were noticeably absent.
The launch of the new collaboration is being co-hosted by WHO Director-General Dr Tedros Adhanom Ghebreyesus, Emmanuel Macron, President of the French Republic, Ursula von der Leyen, President of the European Commission, and the Bill and Melinda Gates Foundation.
The virtual event will include senior United Nations, government and public health and industry leaders from around the world.
World leaders have joined the World Health Organisation in calling for global collaboration to accelerate the development and equitable access to new COVID-19 tools, including vaccines.
I am a doctor: seven years at medical school, three years of applications, four years of doctoral studies to obtain my MD in Belgium, in 1995. From 1997 to 2003, I specialised in anaesthesia-recovery, then in intensive care. For the last 17 years, I have worked in this field, now in the spotlight during this viral pandemic called Covid-19. I am therefore particularly qualified from a medical standpoint. That’s where I stand out, and I am mainly guided in my profession by the motto passed down from the early days of medicine in Antiquity: “Primum non nocere” or in other words: “First, do no harm.”
We asked for a list of all contractors who had a financial interest in providing the agency with reagents and other components of the test. Despite multiple followups, the CDC has not responded.
Reached today, a CDC media staffer said that the agency was overwhelmed with press requests and was working through its backlog. Our questions, she said, were in the queue.
October 18, Event 201. New York. Coronavirus nCoV-2019 Simulation and Emergency Preparedness Task Force, John Hopkins Bloomberg School of Health Security. Big Pharma-Big Money Simulation Exercise sponsored by WEF and Gates Foundation
The source of the virus remains a mystery. General Mark Milley, chairman of the Joint Chiefs of Staff, said on Tuesday that U.S. intelligence indicates that the coronavirus likely occurred naturally, as opposed to being created in a laboratory in China, but there is no certainty either way.
“The idea that it was just a totally natural occurrence is circumstantial. The evidence it leaked from the lab is circumstantial. Right now, the ledger on the side of it leaking from the lab is packed with bullet points and there’s almost nothing on the other side,” the official said.
As my colleague David Ignatius noted, the Chinese government’s original story — that the virus emerged from a seafood market in Wuhan — is shaky. Research by Chinese experts published in the Lancet in January showed the first known patient, identified on Dec. 1, had no connection to the market, nor did more than one-third of the cases in the first large cluster. Also, the market didn’t sell bats.
Vaccines, for Bill Gates, are a strategic philanthropy that feed his many vaccine-related businesses (including Microsoft’s ambition to control a global vaccination ID enterprise) and give him dictatorial control of global health policy.
Now, in a world exclusive interview, Miss Morris reveals how:
Assange watched both children being born in London hospitals via live video link and met Gabriel when he was smuggled into the embassy;
They believe American intelligence agencies tried to steal Gabriel’s DNA from a nappy after becoming suspicious that Assange was his father;
Viele Länder hätten CEPI in den vergangenen zwei Wochen Unterstützung zukommen lassen, „doch benötigt die Koalition für ihre Arbeit mindestens zwei Milliarden Dollar“, so Gates. Die Gates-Stiftung hatte CEPI gemeinsam mit der Wellcome-Stiftung und mehreren Regierungen gegründet.
Lawson discussed how drugmaker Gilead Sciences asked the Food and Drug administration last week to give it the rare „orphan“ status for remdesivir, the company’s experimental coronavirus treatment.
Professor Michel Chossudovsky has looked at who could ultimately benefit from current events and concludes that certain pharmaceutical companies could be (are already) major beneficiaries as they receive lavish funding to develop vaccines. He asks whether we can trust the main actors behind what could amount to a multibillion dollar global (compulsory) vaccination (surveillance) project.
Public health authorities should work with private employers and trusted community leaders such as faith leaders, to promulgate factual information to employees and citizens. Trusted, influential private-sector employers should create the capacity to readily and reliably augment public messaging, manage rumors and misinformation, and amplify credible information to support emergency public communications. National public health agencies should work in close collaboration with WHO to create the capability to rapidly develop and release consistent health messages. For their part, media companies should commit to ensuring that authoritative messages are prioritized and that false messages are suppressed including though the use of technology.
Accomplishing the above goals will require collaboration among governments, international organizations and global business.
(November 06, 2019)
Event 201, hosted by the Johns Hopkins Center for Health Security, envisions a fast-spreading coronavirus with a devastating impact
Watching Hollywood thrillers, you’d think the world was pretty good at protecting the public from deadly microorganisms. We like to believe that somewhere out there, there is a team ready to spring into action – equipped with the latest and best technologies.
Government agents like Jack Bauer in 24. Harvard professors like Robert Langdon in Inferno. And WHO epidemiologists like Dr. Leonora Orantes in Contagion – who even risked getting kidnapped as she pursued “Patient Zero.”
In the real world, though, the health infrastructure we have for normal times breaks down very rapidly during major infectious disease outbreaks. This is especially true in poor countries. But even in the U.S., our response to a pandemic or widespread bioterror attack would be insufficient.
(18. Februar 2017)
When I decided 20 years ago to make global health the focus of my philanthropic work, I didn’t imagine that I’d be speaking at a conference on international security policy. But I’m speaking here at the Munich Security Conference because I believe our worlds are more tightly linked than most people realize.
(19. Januar 2017)
A new coalition to prevent epidemics was launched Wednesday at the World Economic Forum in Davos, with the aim of creating vaccines and other measures to preclude the spread of infectious disease.
The Coalition for Epidemic Preparedness Innovations (CEPI), backed by the governments of Germany, Japan and Norway with support from the Bill & Melinda Gates Foundation, will commit an initial $460 million to “outsmart epidemics,” the coalition said in a statement.
What prevails is an atmosphere of fear and uncertainty which enables powerful financial interests to manipulate the stock market and consolidate their financial positions. This crisis has led to an unprecedented concentration of money wealth.
Event 201 is a pandemic tabletop exercise hosted by The Johns Hopkins Center for Health Security in partnership with the World Economic Forum and the Bill and Melinda Gates Foundation on October 18, 2019, in New York, NY. The exercise illustrated the pandemic preparedness efforts needed to diminish the large-scale economic and societal consequences of a severe pandemic. Drawing from actual events, Event 201 identifies important policy issues and preparedness challenges that could be solved with sufficient political will and attention. These issues were designed in a narrative to engage and educate the participants and the audience.
As COVID-19 worsens, though, expect to see a greater willingness to trade privacy for effective health surveillance, just as 9/11 led to a tightening of security around airports and other public spaces.
„A situation like the pandemic creates a fundamental shift in how people react to technology. This is the direction we are going to be moving in.“
— Labhesh Patel, chief technology officer at Jumio, an ID verification company
The bottom line: We’ve already given up so much in the fight against COVID-19. Some elements of personal privacy may be the next to go — and don’t expect the surveillance to end when the pandemic does.
We should listen to somebody who grew up in a society where there were no civil rights, Angela Merkel, talk about how the current situation justifies restricting our movements. And matters will not stop there: people might have been shocked when they saw China use apps and geolocation to control the movements of its population during the spread of the infection, but we now see Hong Kong, South Korea and Taiwan following suit: their success is being used to justify population control measures that would be completely unacceptable under normal circumstances.
Phases 3 studies of Remdesivir made by U.S. pharmaceutical giant Gilead could take place in South Korea soon.
The recombinant human interferon α 2b (IFN-α2b) produced by Cuban technology is obtained from Escherichia coli.This is the active principle of the product registered in Cuba as Heberon alfa R® trademark (IFN-α2b, CIGB, Havana),which has been successfully used worldwide for the therapy of several viral diseases and neoplasms. Here wedescribe the purity and identity tests used for its molecular characterization.
Developed in 1986 by a team of researchers from the Center for Genetic Engineering and Biotechnology (CIGB), human recombinant Interferon Alfa 2B has benefited thousands of Cuban patients since its introduction into the national health system, and is one of the drugs currently used to combat the new coronavirus COVID-19.
But despite being competitors, the companies’ CEOs seem to have quite a good relationship and consider each other collaborators rather than enemies. Every year, they organize an mRNA conference together that takes turns between Boston and Berlin to bring together all the stakeholders in the field. It was at this year’s edition, in Berlin, that I had the chance to bring them together for an interview regarding the future of mRNA therapies.
The trials will be held at Kaiser Permanente Washington Health Research Institute in Seattle. Testing will involve 45 young, healthy volunteers and it uses Moderna’s mRNA-1273 vaccine.
„Unlike a normal vaccine, RNA vaccines work by introducing an mRNA sequence (the molecule which tells cells what to build) which is coded for a disease-specific antigen, once produced within the body, the antigen is recognized by the immune system, preparing it to fight the real thing,“ according to the University of Cambridge.
Since 2006, the company has been manufacturing mRNA-based vaccines and therapeutics. It is currently looking to boost its manufacturing capacity to supply up to billions of doses during outbreaks.
CureVac chief technology officer Mariola Fotin-Mleczek said: “Nature has invented mechanisms to activate our immune system against infectious diseases. With our unique messenger RNA technology, we mimic nature and give our body the information on how to fight against the virus.
In January 2020, CEPI funded three teams working on a vaccine for SARS-CoV-2, being: Moderna, Inovio Pharmaceuticals, and the University of Queensland (UQ). By February 2020, Inovio announced that it had produced a pre-clinical DNA-based vaccination to fight COVID-19 at its lab in San Diego. Inovio collaborated with a Chinese firm to speed its acceptance by regulatory authorities in China for human trialing. The strategy of the UQ team is to develop a molecular clamp vaccine that genetically modifies viral proteins to make them mimic the coronavirus and stimulate an immune reaction.
In January 2020, CEPI announced a fourth SARS-CoV-2 project in a collaboration with their existing partner CureVac, to develop and manufacture a vaccine.
CureVac in 2015 and 2018 secured financial backing for development projects from its investor the Bill & Melinda Gates Foundation, working on shots to prevent malaria and influenza.
In the field of so-called mRNA therapeutics, CureVac competes with U.S. biotech firm Moderna and German rival BioNTech, which Pfizer has identified as a potential collaboration partner.
CureVac said on its website that CureVac CEO Daniel Menichella met with President Trump and Vice President Pence earlier this month to discuss a coronavirus vaccine. The CEO said at the time he was “very confident that we will be able to develop a potent vaccine candidate within a few months.”
According to the AP, the trial will start testing 45 young, healthy participants with different doses of the vaccine, which was developed by both the NIH and Moderna Inc.
(November 15, 2011)
The four-year DARPA-supported program will exploit CureVac’s RNActive technology along with In-Cell-Art’s nanoparticle expertise and Sanofi’s vaccine development capabilities.
The option agreement signed between Sanofi and CureVac in parallel with the DARPA collaboration covers pre-agreed license terms for the development of vaccines against a number of predefined pathogens.
The Federal Ministry of Education and Research (BMBF) is one of the founding members of the Coalition for Epidemic Preparedness Innovations and has committed a total of 90 million euro to its work. CEPI brings together a range of diverse stakeholders to develop much-needed vaccines for the prevention of future pandemics. Anja Karliczek, Federal Minister of Education and Research, said:
“The Coronavirus is currently the source of concern for many people. The development of a vaccine is an extremely important element in the effort to combat this viral infection. It is encouraging to see that this process now has the support of the international CEPI alliance, which is also making use of German research and development expertise. I hope that good results can soon be achieved for which so many people are waiting at this time.”
While more than two dozen pharmaceutical firms are in a race to develop the first effective vaccine against the coronavirus, CureVac may have an edge thanks to an experimental technology that allows it to deliver the prophylactic in extremely small doses.
It appears to have caught Mr Trump’s eye when he met the company’s chief executive during a crisis summit
(March 15, 2020, 4:54 PM CET)
She declined to comment on any takeover possibilities but referred to Germany’s foreign trade law, under which Berlin can examine takeover bids from non-EU, so-called third countries „if national or European security interests are at stake“.
There was no comment immediately available from the U.S. embassy in Berlin when contacted by Reuters on Sunday over the report, and nobody was available to comment at CureVac. Welt am Sonntag said CureVac declined to comment.
CEPI is a global partnership of public, private and philanthropic organizations; it’s also supporting efforts at the biotech companies Moderna and CureVac.
Even in the rosiest of scenarios, Hatchett says, once the vaccine is in hand, it still needs to get to the people who need it, and that takes time — at least weeks to months, depending on the urgency.
The disease starts in pig farms in Brazil, quietly and slowly at first, but then it starts to spread more rapidly in healthcare settings. When it starts to spread efficiently from person to person in the low-income, densely packed neighborhoods of some of the megacities in South America, the epidemic explodes. It is first exported by air travel to Portugal, the United States, and China and then to many other countries. Although at first some countries are able to control it, it continues to spread and be reintroduced, and eventually no country can maintain control.
There is no possibility of a vaccine being available in the first year.
(November 06, 2019)
Event 201, hosted by the Johns Hopkins Center for Health Security, envisions a fast-spreading coronavirus with a devastating impact
Researchers at a Chinese university identified two separate strains of the Covid-19 coronavirus that could be sickening people in a new study Wednesday, and have called for further research, as 3,200 have died and 93,000 more have been infected by the disease worldwide.
German government sources told Reuters on Sunday that the U.S. administration was looking into how it could gain access to a potential vaccine being developed by a German firm, CureVac.
Earlier, the Welt am Sonntag German newspaper reported that U.S. President Donald Trump had offered funds to lure CureVac to the United States, and the German government was making counter-offers to tempt it to stay.
Privately held Curevac, which was granted up to $8.3 million by CEPI in January, is working to draw on its low-dose vaccine technology, which has showed promise in an early-stage rabies trial, for use against the coronavirus.
The Tuebingen, Germany, based company hopes to have an experimental vaccine ready by June or July to then seek the go-ahead from regulators for testing on humans.
Last Monday, Menichella was among the top executives of nearly a dozen biotech and pharmaceutical companies briefing President Trump on their respective coronavirus drug development plans. Just over a week later, he was out as CEO, replaced by CureVac founder and former CEO Hoerr.
It’s a rapid transition in leadership at a time when the company is in the global spotlight for its efforts to quickly advance a coronavirus vaccine into human testing.
In the Event 201 Simulation of a Coronavirus Pandemic, a 15% collapse of financial markets had been “simulated”.
It was not “predicted” according to the organizers and sponsors of the event.
Private sector initiative. Participation of corporate execs, foundations, financial institutions, Banks, Big Pharma, CIA, CDC, No health officials on behalf of national governments or the WHO. The simulation exercise was held on the same day as the opening of the CISM World Militaty Sports Games in Wuhan.
Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses evolved into two major types (designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. Although the L type (∼70%) is more prevalent than the S type (∼30%), the S type was found to be the ancestral version. Whereas the L type was more prevalent in the early stages of the outbreak in Wuhan, the frequency of the L type decreased after early January 2020.
The paper said the difference between the two subtypes is at the 28144 position of the viral RNA genome.
The L subtype was more common in the early stages of the outbreak in Wuhan, but the frequency of the L subtype decreased after early January 2020.
The team includes researchers Alessia Loi, Annalisa Bergna and Arianna Gabrieli, all three on short term contracts, together with their Polish colleague Maciej Tarkowski and Professor Gianguglielmo Zehender.
Galli said they had worked non stop since Sunday.
„A group of researchers from Milan’s University Hospital was able to identify the strain of the Italian virus. The researchers state that when compared to what was known about the Chinese virus, a mutation has occured and this discovery will allow to reach(?) the genetic code of the virus, its specific characteristics in order to find out the time and spread speed of the virus. This should be an important first step to develop specific treatment for the infected. The scientific community has already communicated this discovery to Brussels [to the European Union headquarters] and even President Materelli has already congratulated the researchers (…)“
The FBI will provide DHS with the DNA collection kits, analyze the samples, and ensure that law enforcement agencies use the results in accordance with the FBI’s stringent CODIS privacy requirements.
What if the United States government took the DNA of vast numbers of Americans for use without their consent? The Trump administration has just brought us one step closer to that dystopia.
A new study reveals yet another major unintended effect from the CRISPR-Cas9 gene editing tool – with potentially serious implications for the food safety of gene-edited plants. The study found that CRISPR-Cas9 edits intended to knockout the function of a gene fail to do so. Instead, proteins are still produced from the damaged genes, many of which are still functional. The result could be the production of gene-edited plants that are toxic or allergenic.
He Jiankui’s manuscript shows how he ignored ethical and scientific norms in creating the gene-edited twins Lulu and Nana.
Despite biophysicist’s claims, team failed to reproduce changes to make twin girls HIV immune, excerpts from manuscript show
Birth of gene-edited babies Lula and Nana sent shock waves through scientific world in 2018
The fund will seek to close that investment gap by providing equity and grant funding to early stage firms in so-called deep tech, such as manufacturing, biotechnology, health-tech and artificial intelligence, he said. It’s set to formally launch in 2021 and will be run by the European Innovation Council, though the final size could change depending on the outcome of budget talks with the bloc’s member states.
Brazilian farmers are wary of the imminent introduction of a new genetically modified soy seed technology because of the risks associated with dicamba, a herbicide the biotech product is designed to tolerate. Widely used in the United States, dicamba has been described as a volatile product that drifts off easily and may compromise non-tolerant soybeans.
According to a 2013 survey, 30 states and the federal government permitted the analysis of DNA samples collected from individuals who are arrested or charged, but not convicted, of certain crimes. These databases generally did not include low-level offenders.
New York State law requires a conviction before someone’s DNA can be included in the state-operated DNA databank. But databases built by local authorities are not subject to the state rules.
Wait — what?
While it sounds like something out of the movie Gattaca, the “Nobel Prize Sperm Bank” really was operational for 20 years, from 1979 to 1999, and based in Escondido, California. It was founded by the multimillionaire optometrist and inventor Robert Graham, an admirer of eugenics who believed the human race was getting progressively dumber and that the only way to stop it was by filling the world with the genetic descendants of Nobel Prize winners.
Mr. Epstein’s vision reflected his longstanding fascination with what has become known as transhumanism: the science of improving the human population through technologies like genetic engineering and artificial intelligence. Critics have likened transhumanism to a modern-day version of eugenics, the discredited field of improving the human race through controlled breeding.
Der Tod von Suzanne Eaton, Wissenschaftlerin am Max-Planck-Institut für molekulare Zellbiologie und Genetik und am Biotechnologischen Zentrum der TU Dresden, ist leider Gewissheit. Das MPI teilte mit, dass die Polizei ihre Leiche am Abend des 8. Juli gefunden hat. Die Behörden haben ihre Untersuchung der Vorkommnisse, die sich am Nachmittag des 2. Juli ereignet haben könnten, noch nicht abgeschlossen.
On Sunday, hundreds of “March Against Monsanto” rallies are expected around the world. The campaign group of the same name behind the protests aims to “educate the world about the crimes Monsanto has committed against humanity”.
The marches – which attract people in their millions – are in their eighth year.
(1.2.2019) As BuzzFeed reports, this week FamilyTreeDNA confirmed that it is working with the FBI and allowing local law enforcement access to its genealogy database. The number of DNA profiles stored in that database is thought to total over a million.
(21.1.2019) The science-fiction future, in which police can swiftly identify robbers and murderers from discarded soda cans and cigarette butts, has arrived. In 2017, President Trump signed into law the Rapid DNA Act, which, starting this year, will enable approved police booking stations in several states to connect their Rapid DNA machines to Codis, the national DNA database. Genetic fingerprinting is set to become as routine as the old-fashioned kind.
(13. April 2016) 23andMe has about 1.2 million customers. Ancestry DNA was aiming for 1.3 million by the end of 2015 and we can only assume they’ve reached that number by now. The Family Tree DNA database has just over 783,000 records. Assuming there is no overlap between these 3 databases, this means that if all 3 of these companies combined their databases we would have around 3.28 million DNA profiles, or just 1% of the U.S. population. This means that with all the hype around DNA testing companies, they have only managed to achieve a 1% market share combined in the USA alone.
So are these the biggest DNA databases? The answer is no. The U.S. government actually owns the biggest DNA database by far.
(18. April 2009)
The F.B.I., with a DNA database of 6.7 million profiles, expects to accelerate its growth rate from 80,000 new entries a year to 1.2 million by 2012 — a 15-fold increase. F.B.I. officials say they expect DNA processing backlogs — which now stand at more than 500,000 cases — to increase.
Law enforcement officials say that expanding the DNA databanks to include legally innocent people will help solve more violent crimes.
(3.1.2019) At the same time, computational biologist Tony Capra at Vanderbilt University in Nashville had the same bright idea to search for Neanderthal DNA in a large database. He used proprietary electronic records of 28,000 Americans. His team was the first to publish, reporting Neanderthal DNA variants that raise the risk of depression, skin lesions, blood clots, and other disorders in people today.
(15.5.2017) The issue of DNA collection has received some press attention. In one case in Shandong province, police collected DNA from more than 5,000 male students in one college in October 2013. The students were given no explanation about why their information was taken, and many “did not understand nor felt comfortable about it.” When reached by journalists, the school said it was to cooperate with the police’s request to establish a database about migrant populations, but the police said it was to solve a number of theft cases on the campus.
(23.2.2019) When George Orwell’s “1984” was published seven decades ago, it seemed a dire warning of a future dystopia ruled by thought police and authoritarian control. Today, such a world is becoming a reality in Xinjiang. We agree with human rights groups who have urged the United Nations Human Rights Council, when it meets starting Monday, to launch an international fact-finding mission to Xinjiang to expose this unsettling experiment in state control of human behavior.