The goal of this paper is to address the question whether SARS-CoV-2 originated from an animal-to-human spillover or from experiments performed in a laboratory. In the latter scenario, it is possible that evidence exists for manipulation of the viral genome by common laboratory techniques. SARS-CoV-2 is a large RNA virus. To create infectious versions of CoVs, the entire 30kb RNA genome is reconstructed in DNA by in vitro genome assembly (IVGA). IVGA has been used to create reverse genetic systems for modified and chimeric RNA viruses for more than 20 years (Yount et al, 2000). Most importantly, IVGA methods can leave genetic fingerprints, and we find those fingerprints in the genome of SARS-CoV-2.