(DEc 3, 2020)
Pfizer chairman Albert Bourla told Dateline host Lester Holt that the pharmaceutical company was “not certain” if the vaccine prevented the coronavirus from being transmitted, saying, “This is something that needs to be examined.”
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(DEc 3, 2020)
Pfizer chairman Albert Bourla told Dateline host Lester Holt that the pharmaceutical company was “not certain” if the vaccine prevented the coronavirus from being transmitted, saying, “This is something that needs to be examined.”
(29.08.2020)
Most tests set the limit at 40, a few at 37. This means that you are positive for the coronavirus if the test process required up to 40 cycles, or 37, to detect the virus.
Tests with thresholds so high may detect not just live virus but also genetic fragments, leftovers from infection that pose no particular risk — akin to finding a hair in a room long after a person has left, Dr. Mina said.
Any test with a cycle threshold above 35 is too sensitive, agreed Juliet Morrison, a virologist at the University of California, Riverside. “I’m shocked that people would think that 40 could represent a positive,” she said.
Description of the problem: WHO requests users to follow the instructions for use (IFU) when interpreting results for specimens tested using PCR methodology.
Users of IVDs must read and follow the IFU carefully to determine if manual adjustment of the PCR positivity threshold is recommended by the manufacturer.
WHO guidance Diagnostic testing for SARS-CoV-2 states that careful interpretation of weak positive results is needed (1). The cycle threshold (Ct) needed to detect virus is inversely proportional to the patient’s viral load. Where test results do not correspond with the clinical presentation, a new specimen should be taken and retested using the same or different NAT technology.
A laboratory study found that the 501Y.V2 variant achieved „complete escape“ from monoclonal antibodies, the man-made proteins that act like the antibodies produced by jabs.
Boris Johnson said he was holding „intensive talks“ with scientists about the new variants. The Prime Minister told MPs he was confident that the Medicines and Healthcare products Regulatory Agency (MHRA) was capable of approving new vaccine modifications as quickly as necessary.
“We don’t know yet whether an individual can, although not becoming ill from the virus because they have been vaccinated, still catch it and spread it on to others.
Asked whether people who had received the jab could hug their children, Janet Lord, director of Birmingham University’s Institute of Inflammation and Ageing, said: “I would certainly advise not to do that at the moment because as you probably know with the vaccines they take several weeks before they are maximally effective.“
(05.12.2020)
In order to halt the spread of coronavirus completely, a vaccine would need to produce antibodies that stop the virus from replicating. „To prevent asymptomatic infection and transmission, you need what’s called sterilizing immunity,“ Greg Poland, MD, director of the Mayo Clinic’s Vaccine Research Group, explained to USA Today. While it’s possible that one or more of the vaccines could produce sterilizing immunity, it currently remains unproven.
(14.01.2021)
The peer reviewed study was published in the European Journal of Clinical Investigation on January 5, and analyzed coronavirus case growth in 10 countries in early 2020.
The study compared cases in England, France, Germany, Iran, Italy, Netherlands, Spain and the U.S. – all countries that implemented mandatory lockdown orders and business closures – to South Korea and Sweden, which instituted less severe, voluntary responses. It aimed to analyze the effect that less restrictive or more restrictive measures had on changing individual behavior and curbing the transmission of the virus.
(16.07.2020)
Ms Alfaro added that the outbreak may have been exacerbated by the fishermen’s hardiness and acclimatisation to rough conditions, in that they may have spent significant time in discomfort without recognising or acknowledging symptoms.
(02.11.2020)
The finding adds credence to the theory the mutation, which accounts for 85 per cent of global cases, is more contagious than the original strain.
D614G is by far the most common strain of coronavirus affecting humans worldwide and first appeared in February in Europe.
The world needs an inquiry that considers not just natural origins but the possibility that SARS-CoV-2, the virus that causes Covid-19, escaped from a laboratory. The WHO team, however, plans to build on reports by Chinese scientists rather than mount an independent investigation. Given that Chinese authorities have been slow to release information, penalized scientists and doctors who shared clinical and genomic details of the novel coronavirus, and have since demonstrated a keen interest in controlling the narrative of how the virus emerged, this is not a promising foundation for WHO’s investigation.
(released 05.01.2021)
Conclusions: While small benefits cannot be excluded, we do not find significant benefits on case growth of more restrictive NPIs. Similar reductions in case growth may be achievable with less restrictive interventions.
(21.12.2020)
Much of the following list has been put together by data engineer Ivor Cummins, who has waged a year-long educational effort to upend intellectual support for lockdowns. AIER has added its own and the summaries. The upshot is that the virus is going to do as viruses do, same as always in the history of infectious disease. We have extremely limited control over them, and that which we do have is bound up with time and place. Fear, panic, and coercion are not ideal strategies for managing viruses. Intelligence and medical therapeutics fare much better.
(These studies are focused only on lockdown and their relationship to virus control. They do not get into the myriad associated issues that have vexed the world such as mask mandates, PCR-testing issues, death misclassification problem, or any particular issues associated with travel restrictions, restaurant closures, and hundreds of other particulars about which whole libraries will be written in the future.)
(26.11.2020)
Let’s put this in perspective. First, a relative risk reduction is being reported, not absolute risk reduction, which appears to be less than 1%. Second, these results refer to the trials’ primary endpoint of covid-19 of essentially any severity, and importantly not the vaccine’s ability to save lives, nor the ability to prevent infection, nor the efficacy in important subgroups (e.g. frail elderly). Those still remain unknown.
(08.06.2020)
Neutralizing antibodies prevent the virus from replicating.
(11.11.2020)
A vaccine that protects against symptoms of Covid-19 could contribute to the spread of the disease if — and this is still just an if — the people who get vaccinated remain capable of carrying and transmitting the virus. That’s a risk that’s gotten little attention amid the deserved jubilation over a Nov. 9 report from Pfizer Inc. and BioNTech SE that their vaccine candidate appears to be highly effective.
Chris Whitty, England’s chief medical officer, told a press conference that London was being moved to more stringent Tier 3 restrictions because cases were surging in and around the capital — and not directly in response to the discovery of the new variant.
(29.10.2020)
Currently, 20A.EU1 accounts for 90% of sequences from the UK, 60% of sequences from Ireland, and between 30 and 40% of sequences in Switzerland and the Netherlands. This makes this variant currently one of the most prevalent in Europe. It has also been identified in France, Belgium, Germany, Italy, Latvia, Norway, and Sweden.
(30.10.2020)
Research showed that the Spanish strain accounted for 90 percent of sequences from the UK, 60 percent from Ireland, 40 percent from the Netherlands, 30 percent from Switzerland and has been identified in Belgium, France, Germany, Italy, Latvia, Norway, and Sweden.
(02.11.2020)
The finding adds credence to the theory the mutation, which accounts for 85 per cent of global cases, is more contagious than the original strain.
D614G is by far the most common strain of coronavirus affecting humans worldwide and first appeared in February in Europe.
However, there have been three that have caught scientists‘ attention:
D614G
D614G is by far the most common strain of coronavirus affecting humans worldwide and first appeared in February in Germany.
It is thought to account for 85 per cent of global cases.
The D614G mutation sprung up at one specific location, position 614, on the spike protein of the virus, in a European patient.
This viral spike hijacks the human receptor ACE2 and this is how it infects human cells.
(29.08.2020)
Most tests set the limit at 40, a few at 37. This means that you are positive for the coronavirus if the test process required up to 40 cycles, or 37, to detect the virus.
Tests with thresholds so high may detect not just live virus but also genetic fragments, leftovers from infection that pose no particular risk — akin to finding a hair in a room long after a person has left, Dr. Mina said.
Any test with a cycle threshold above 35 is too sensitive, agreed Juliet Morrison, a virologist at the University of California, Riverside. “I’m shocked that people would think that 40 could represent a positive,” she said.
(26.11.2020)
Let’s put this in perspective. First, a relative risk reduction is being reported, not absolute risk reduction, which appears to be less than 1%. Second, these results refer to the trials’ primary endpoint of covid-19 of essentially any severity, and importantly not the vaccine’s ability to save lives, nor the ability to prevent infection, nor the efficacy in important subgroups (e.g. frail elderly). Those still remain unknown. Third, these results reflect a time point relatively soon after vaccination, and we know nothing about vaccine performance at 3, 6, or 12 months, so cannot compare these efficacy numbers against other vaccines like influenza vaccines (which are judged over a season). Fourth, children, adolescents, and immunocompromised individuals were largely excluded from the trials, so we still lack any data on these important populations.
I previously argued that the trials are studying the wrong endpoint, and for an urgent need to correct course and study more important endpoints like prevention of severe disease and transmission in high risk people. Yet, despite the existence of regulatory mechanisms for ensuring vaccine access while keeping the authorization bar high (which would allow placebo-controlled trials to continue long enough to answer the important question), it’s hard to avoid the impression that sponsors are claiming victory and wrapping up their trials (Pfizer has already sent trial participants a letter discussing “crossing over” from placebo to vaccine), and the FDA will now be under enormous pressure to rapidly authorize the vaccines.
Determining whether a vaccine can protect against severe disease and death from COVID-19 may not be possible in phase 3 clinical trials and will often require long-term, ongoing studies after widespread deployment of a vaccine.
To ensure ongoing evaluation of vaccine safety, well-supported pharmacovigilance studies after licensure will be necessary.
Pfizer chairman Albert Bourla told Dateline host Lester Holt that the pharmaceutical company was “not certain” if the vaccine prevented the coronavirus from being transmitted, saying, “This is something that needs to be examined.”
– Government data shows there were 1,230 coronavirus patients needing NHS treatment every day in England
– But only 938 of these were from ‚the community‘, meaning they definitely caught the virus in day-to-day life
He said: ‘The thing was built with French help, so don’t think that there aren’t some monitoring devices in there. I think what you are going to find out is that these guys were doing experiments which they weren’t fully authorised [for] or knew what they were doing and that somehow, either through an inadvertent mistake, or on a lab technician, one of these things got out.
‘It’s not that hard for these viruses to get out. That is why these labs are so dangerous.
‘You essentially had a biological Chernobyl in Wuhan, but the centre of gravity, the Ground Zero, was round the Wuhan lab, in terms of the casualty rates. And like Chernobyl, you also had the cover-up – the state apparatus reports to itself and just protects itself.’
(20.06.2020)
Of the six, at least two of them are Secret Service agents, according to a law enforcement official.
While more than two weeks have passed, one health district director thinks it’s still too soon to draw conclusions on the effect large protests have on the number of coronavirus cases in Virginia.
Olzewski also noted:
„Ventilators are likely to be the leading cause of death in the pandemic. Sedatives and paralytics combined with barro-trauma from pressurized air kill 90 percent of those vented at Elmhurst (and by extension, much of the world).
Nosocomial (in-hospital) infection is the main vector of transmission. At Elmhurst, “Covid Rule-Out” and “Covid Confirmed” are housed in the same rooms. PPE is not changed between patients. Rooms are not properly or even marginally cleaned after Covid deaths.
Isolated from family, patients at Elmhurst who do not have “Do Not Resuscitate” orders are being treated as though they did. Nurses were told not to perform CPR on at least one “full code” patient, in violation of their oaths and licenses.
Delayed treatment due to the government mandate to stay inside, and the government recommendation to not seek early outpatient help, combined with the restriction in New York and elsewhere on promising, even proven therapies during the early stages of illness, massively compounds the death rate.
Much of which points to what may be the real reason black and brown Americans seem to be disproportionately affected by COVID-19. They are likely not dying because of some alleged genetic predisposition or a peculiar array of Covi-combustible comorbidities. But they are certainly dying from an underlying condition: a defunded, criminally negligent, and corrupt hospital system, which during this crisis seems to take extra pains to do them in, and which may be financially incentivized to do so.“
„HIgher ups“ were overriding a patient’s full code status! Erin Marie RN exposes the malfeasance and callous disregard for human life in this fiasco.
Erin Marie Olszewski is a Nurse-turned-investigative journalist, who has spent the last few months on the frontlines of the coronavirus pandemic, on the inside in two radically different settings.
(09.06.2020)
Erin Marie Olszewski is a Nurse-turned-investigative journalist, who has spent the last few months on the frontlines of the coronavirus pandemic, on the inside in two radically different settings. Two hospitals. One private, the other public. One in Florida, the other in New York.
And not just any New York public hospital, but the „epicenter of the epicenter“ itself, the infamous Elmhurst in Donald Trump’s Queens. As a result of these diametrically opposed experiences, she has the ultimate „perspective on the pandemic“. She has been where there have been the most deaths attributed to Covid-19 and where there have been the least.
(11.06.2020)
Erin enlisted in the Army when she was 17. She deployed in support of Operation Iraqi Freedom in 2003. Part of her duties involved overseeing aid disbursement and improvements to hospital facilities. While in country she received the Army Commendation Medal for meritorious service, and was wounded in combat. Erin eventually retired as a sergeant, and became a civilian nurse in 2012.
(today)
Nationwide, more than 45,500 residents and staff have died from coronavirus outbreaks at nursing homes and other long-term care facilities, according to a running count by The Associated Press. That’s about 40% of more than 115,000 total deaths. Nursing home residents are less than 1% of the U.S. population.
(26.05.2020)
At least 4,900 seniors have died in New York State nursing homes from the coronavirus so far this year.
Around 20 percent of all New York state deaths were in nursing homes.
Van Kerkhove’s answer on Monday had provoked a flurry of criticism and worry from public health experts on Twitter who worried that the WHO was giving the public the wrong impression.
The Knesset announced on Thursday morning that all committee meetings scheduled for the day were postponed and that workers were instructed not to come to in unless it was essential to do so.
Dr. Robert Redfield, the head of the Centers for Disease Control and Prevention, and Dr. Stephen Hahn, the commissioner of the Food and Drug Administration, will testify by video conference at a Senate hearing about the coronavirus next week.
A spokesperson for DHS reportedly declined to comment on the number of cases.
He will be staying at home and teleworking while wearing a mask continually for 14 days.
U.S. Food and Drug Administration Commissioner Stephen Hahn is in self-quarantine for a couple of weeks after coming into contact with someone who tested positive for COVID-19, an FDA spokesman told Reuters late on Friday.
Dr. Robert Redfield, the head of the Centers for Disease Control and Prevention, will self-quarantine for two weeks after he was exposed to a person at the White House who tested positive for Covid-19, a CDC spokesperson confirmed to CNN.
President Donald Trump hoped this would be the week he emerged into a nation recovering from pandemic. Instead the pandemic came to him.
Miller’s positive test prompted the vice president to delay his takeoff for a trip to Iowa. Six staffers who may have had contact with her deplaned, and all six later tested negative for the virus.
The positive tests reflect the dangers of the virus spreading inside the White House complex, and it further called into question what measures are being taken to try and limit the exposure of the top two elected officials in American government.
Miller is one of Pence’s closest aides and is married to Stephen Miller, one of Trump’s senior advisers.
(07.05.2020)
President Trump said he and Vice President Mike Pence, as well as the White House staff, would now be tested on a daily basis.
“The entire Intelligence Community has been consistently providing critical support to U.S. policymakers and those responding to the COVID-19 virus, which originated in China. The Intelligence Community also concurs with the wide scientific consensus that the COVID-19 virus was not manmade or genetically modified.
“As we do in all crises, the Community’s experts respond by surging resources and producing critical intelligence on issues vital to U.S. national security. The IC will continue to rigorously examine emerging information and intelligence to determine whether the outbreak began through contact with infected animals or if it was the result of an accident at a laboratory in Wuhan.”
In an unusual public statement, the Office of the Director of National Intelligence, or ODNI, also said that U.S. intelligence agencies concur with the broad scientific consensus that “the Covid-19 virus was not manmade or genetically modified.”
“It’s far more likely that Mother Nature is just a step ahead of us and has created a novel pathogen, now able to move quite effectively from human to human,” said Jason Rao, a biosecurity specialist, former senior policy adviser to President Barack Obama and executive director of Health Security Partners, a D.C.-based nonprofit organization focused on global biological threat reduction.
The New York Times reported in 2018 that American and Ukranian government officials expressed concern about whether Bryan was being co-opted by a Ukranian company seen as aligned with an oligarch …
The game-changing findings of the joint effort between the DHS’s Science and Technology directorate and Donald Trump’s coronavirus task force was revealed at Thursday’s White House press briefing.
The virus dies quickest in the presence of direct sunlight, and it survives best in indoor conditions, the study found.
(18.04.2020)
Those practices made the tests sent to public health labs unusable because they were contaminated with the coronavirus, and produced some inconclusive results.
(06.04.2020)
Imagine that you are not carrying the virus, but you go in for testing and leave carrying the virus.
The Telegraph report stated that it is “not clear” how the tests were contaminated.
(30.04.2020)
One of the suppliers – the Luxembourg-based firm Eurofins – sent an email on Monday morning to government laboratories in the UK warning that a delivery of key components called “probes and primers” had been contaminated with coronavirus and would be delayed.
The firm admitted there had been “an issue” and insisted other private providers had suffered the same problem.
(05.03.2020)
The FDA’s director of the Office of In Vitro Diagnostics and Radiological Health, Timothy Stenzel, flew to CDC headquarters in Atlanta on the weekend of Feb. 22, but he was immediately forced to wait overnight as health department officials lobbied the CDC to give him access to the agency’s campus, according to Politico. Stenzel was there specifically to work out issues with the CDC’s coronavirus test that had already hobbled more expansive screening for weeks.
(01.03.2020)
A senior administration official added that the government also moved the manufacturing of the coronavirus tests out of the Atlanta laboratory of CDC.
The official said that the CDC engaged with a third party contractor on Feb. 20 to help manufacture the testing kits. The official added that the FDA regulator, Stenzel, visited the Atlanta laboratory on Feb. 22.
In 2006, Barrick Gold had proposed moving the glacier ice from the Toro 1, Toro 2 and the Esperanza glaciers to facilitate their exploitation of the region’s resources.
The case is County of Los Angeles et al v Monsanto Co et al, U.S. District Court, Central District of California, No. 19-04694.
The World Magnetic Model (WMM) is a standard model of the core and large-scale crustal magnetic field. It is used extensively for navigation and in attitude and heading referencing systems by the UK Ministry of Defence, the US Department of Defense, the North Atlantic Treaty Organization and the International Hydrographic Organization.
(…)
The WMM is a model of the core and large-scale crustal fields only. However the satellite data contain unwanted signals such as small-scale crustal, external ionospheric and magnetospheric and their induced counterparts. These fields would have added noise to the WMM2015 SV model and could have biased its estimates.
BGS employed two techniques to avoid the contamination caused by external magnetic fields. Firstly we rejected those data most contaminated by these sources, as identified by a combination of local time, geomagnetic indices and solar wind data. ……..