Daily Archives: 20. September 2023


20.09.2023 - 23:00 [ Nachrichtenagentur Radio Utopie ]

Note: internet boycott of Britain

On September 19, 2023, the UK House of Commons passed the so-called „online safety bill“. This law puts everyone in reach, not just in Britain, under arbitary espionage by maximum cynic dialectic excuses (abuse of power because of abuse of power).

Who surrenders, surrenders. You do that on your own account.

This news agency will not link to UK based sources anymore. Furthermore, we advise everyone to not use british based DNS servers or any other online service, business or provider. Join the internet boycott of Britain.

If the next state authority, or the councils governmental of the EU bloc comes around with similar laws and orders, they know what happens next.

20.09.2023 - 22:38 [ Electronic Frontier Foundation ]

Today The UK Parliament Undermined The Privacy, Security, And Freedom Of All Internet Users

(19.09.2023)

The bill could empower the government to undermine not just the privacy and security of U.K. residents, but internet users worldwide.

A clause of the bill allows Ofcom, the British telecom regulator, to serve a notice requiring tech companies to scan their users–all of them–for child abuse content.This would affect even messages and files that are end-to-end encrypted to protect user privacy. As enacted, the OSB allows the government to force companies to build technology that can scan regardless of encryption–in other words, build a backdoor.

20.09.2023 - 21:48 [ Netzpolitik.org ]

Britisches Parlament beschließt Online Safety Bill

Das rund sechs Jahre lang verhandelte Gesetz ist inzwischen auf gut 300 Seiten angewachsen und trifft nicht nur große Online-Dienste wie Facebook oder Google. Schätzungen der konservativen Regierung zufolge sind rund 20.000 kleinere und nicht-kommerzielle Anbieter wie die Wikipedia betroffen. Viele davon machen sind nun Sorgen, ob sie die Vorgaben überhaupt umsetzen können, für manche kommt sogar ein Rückzug aus dem Internet für britische Nutzer:innen in Frage.

20.09.2023 - 21:28 [ CNN ]

Biden invites Netanyahu to Washington following months of tensions over Israeli PM’s judicial reform efforts

Biden offered his counterpart a warm, cordial welcome as he said they would discuss “some of the hard issues,” including “checks and balances,” a reference to the Israeli leader’s judicial reform efforts which have been a source of significant tensions between the countries.

“Today, we’re going to discuss some of the hard issues. And that is upholding democratic values that lie at the heart of our partnership, including checks and balances in our systems, and preserving the path to a negotiated two-state solution, and ensuring that Iran never, never acquires a nuclear weapon,” Biden said.

20.09.2023 - 21:12 [ i24news.tv ]

Netanyahu meets Zelensky, Erdogan on sidelines of UNGA

Prime Minister Benjamin Netanyahu met Ukrainian President Volodymyr Zelensky and Turkish President Recep Tayyip Erdogan on the sidelines of the UN General Assembly in New York on Tuesday.

On encountering the Israeli delegation, the Ukrainian leader made note of the „very big team“ receiving him, which included Israel‘s Ambassador to the UN Gilad Erdan and Mossad chief David Barnea.

20.09.2023 - 20:58 [ Yahoo.com ]

Federal Reserve leaves interest rates unchanged at 22-year high, signals one more hike in ‘23

The Federal Reserve held interest rates steady at a 22-year high on Wednesday while signaling another rate hike will be needed later this year to bring inflation back to its 2% target.

20.09.2023 - 05:00 [ White House ]

Remarks by President Biden Before the 78th Session of the United Nations General Assembly | New York, NY

But upgrading and strengthening our institutions, that’s only half of the picture. We must also forge new partnerships, confront new challenges.

Emerging technologies, such as artificial intelligence, hold both enormous potential and enormous peril. We need to be sure they are used as tools of opportunity, not as weapons of oppression.

Together with leaders around the world, the United States is working to strengthen rules and policies so AI technologies are safe before they are released to the public; to make sure we govern this technology — not the other way around, having it govern us.

And I’m committed to working through this institution and other international bodies and directly with leaders around the world, including our competitors, to ensure we harness the power of A- — artificial intelligence for good, while protecting our citizens from its most profound risk.

It’s going to take all of us. I’ve been working at this for a while, as many of you have. It’s going to take all of us to get this right.

20.09.2023 - 04:53 [ Fox News ]

President Biden warns UN to ‚make sure‘ AI does not ‘govern us’

President Biden warned the U.N. General Assembly Tuesday that the world needs to make sure it governs artificial intelligence and „not the other way around, having it govern us.“

Biden, speaking in New York City, said „emerging technologies such as artificial intelligence hold both enormous potential and enormous peril.“

20.09.2023 - 04:47 [ Sony Pictures / Youtube ]

GATTACA (1997) – First 10 Minutes

Ethan Hawke, Uma Thurman, Alan Arkin and Jude Law star in this engrossing sci-fi thriller about an all-too-human man who dares to defy a system obsessed with genetic perfection.

20.09.2023 - 04:33 [ ORF.at ]

KI bestimmt Risiko für genetische Erkrankungen

(19.09.2023)

Die Suche nach den Ursachen für genetische Erkrankungen ist ein großes Unterfangen, bei dem vermehrt auch künstliche Intelligenz (KI) zum Einsatz kommt. Ein neues KI-Werkzeug von Google DeepMind kann das Krankheitsrisiko abschätzen, das von bestimmten Genmutationen ausgeht. Die entstandene Datenbank soll künftige Untersuchungen zur Entstehung der Krankheiten deutlich erleichtern.

20.09.2023 - 04:25 [ European Bioinformatics Institute / European Molecular Biology Laboratory ]

New predictions of genetic variant pathogenicity using AlphaFold protein structures

(19.09.2023)

Google DeepMind has developed a new tool called AlphaMissense, which uses the AlphaFold human protein structure models to predict whether a sequence variant which changes one amino acid in a protein is likely to be tolerated or to impact protein function.

The Ensembl Variant Effect Predictor now integrates Google DeepMind’s new AlphaMissense Catalogue.

20.09.2023 - 04:19 [ endpts.com ]

Al­phaFold, meet Al­phaMis­sense: Google Deep­Mind‘s AI suc­ces­sor pre­dicts how 71M mu­ta­tions cause dis­ease

Google Deep­Mind has de­vel­oped an AI sys­tem that pre­dicts the chances that tens of mil­lions of ge­net­ic vari­ants will cause dis­ease.

20.09.2023 - 03:49 [ European Bioinformatics Institute / European Molecular Biology Laboratory ]

A more diverse human reference genome

(10 May 2023)

The work was led by the international Human Pangenome Reference Consortium (HPRC), a group funded by the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH) and consisting of 14 institutes, including EMBL’s European Bioinformatics Institute (EMBL-EBI). (…)

The majority of the genomes used to create the human pangenome reference were collected as part of the 1000 genomes project, the largest public catalogue of human variation and genotype data from a wide range of populations. (…)

In order to understand the differences in the genes present across the individual genomes represented in the human pangenome, researchers in EMBL-EBI’s Ensembl team needed to map the high-quality annotations on the reference human genome generated as part of the GENCODE project, across the pangenome.

20.09.2023 - 03:12 [ Wikipedia ]

1000 Genomes Project

Some genomic differences may not affect fitness. Neutral variation, previously thought to be “junk” DNA, is unaffected by natural selection resulting in higher genetic variation at such sites when compared to sites where variation does influence fitness.[14]

It is not fully clear how natural selection has shaped population differences; however, genetic candidate regions under selection have been identified recently. (…)

It was found that on average, each person carries around 250–300 loss-of-function variants in annotated genes and 50-100 variants previously implicated in inherited disorders. Based on the two trios, it is estimated that the rate of de novo germline mutation is approximately 10−8 per base per generation.

20.09.2023 - 02:51 [ National Library of Medicine / National Institutes of Health (NIH) ]

The 1000 Genomes Project: Welcome to a New World

(Dec 2015)

“Now this is not the end… But it is, perhaps, the end of the beginning” as Winston Churchill said. Large-scale sequencing projects will continue for more regional or ethnic groups, in order to extend the global coverage. Much effort will focus on a better understanding of the relationship between genetic variation and common disorders. The translation of this massive genetic information to human health will benefit from the development of complex databases gathering genetic, clinical, and biological data, such as multi-omics profiles, while maintaining protection of potentially sensitive personal information (3). Efforts are also underway to increase genetic awareness in the public and to educate health professionals

20.09.2023 - 02:12 [ GENCODE project ]

GENCODE

The goal of the GENCODE project is to identify and classify all gene features in the human and mouse genomes with high accuracy based on biological evidence, and to release these annotations for the benefit of biomedical research and genome interpretation.

20.09.2023 - 01:59 [ European Molecular Biology Laboratory ]

The Human Genome Project at 20: interview with Ewan Birney

(25 April 2023)

EMBL-EBI Director Ewan Birney was a graduate student in the 90s, when the Human Genome Project was in full swing. On the project’s 20th anniversary, he shares his memories of the slow but incredibly accurate analysis software he developed, how the private initiative sped up the public one, and how a betting book highlighted how little we knew about the human genome at the time.

20.09.2023 - 01:45 [ European Molecular Biology Laboratory ]

DeepMind and EMBL release the most complete database of predicted 3D structures of human proteins

(22 July 2021)

For those scientists who rely on experimental protein structure determination, AlphaFold’s predictions have helped accelerate their research. For example, a team at the University of Colorado Boulder is finding promise in using AlphaFold predictions to study antibiotic resistance, while a group at the University of California San Francisco has used them to increase their understanding of SARS-CoV-2 biology.

The AlphaFold Protein Structure Database builds on many contributions from the international scientific community, as well as AlphaFold’s sophisticated algorithmic innovations and EMBL-EBI’s decades of experience in sharing the world’s biological data. DeepMind and EMBL’s European Bioinformatics Institute (EMBL-EBI) are providing access to AlphaFold’s predictions so that others can use the system as a tool to enable and accelerate research and open up completely new avenues of scientific discovery.