For the purpose of this surveillance, a vaccine breakthrough infection is defined as the detection of SARS-CoV-2 RNA or antigen in a respiratory specimen collected from a person ≥14 days after they have completed all recommended doses of a U.S. Food and Drug Administration (FDA)-authorized COVID-19 vaccine.
Identifying and investigating hospitalized or fatal vaccine breakthrough cases
CDC monitors reported hospitalized or fatal vaccine breakthrough cases for clustering by patient demographics, geographic location, time since vaccination, vaccine type, and SARS-CoV-2 lineage. Reported data include hospitalized or fatal breakthrough cases due to any cause, including causes not related to COVID-19.
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Hospitalized or fatal COVID-19 vaccine breakthrough cases reported to CDC as of August 30, 2021
As of August 30, 2021, more than 173 million people in the United States had been fully vaccinated against COVID-19.
During the same time, CDC received reports from 49 U.S. states and territories of 12,908 patients with COVID-19 vaccine breakthrough infection who were hospitalized or died.