The Gaza war and its aftermath in Lebanon and Syria seem to have strengthened the hands of Israel and Turkey, while weakening those of Iran and its allies. At the same time, the return of Trump appears to have brought the US even closer to Israel, and upped its opposition to Iran.
But how much this is truly a departure from the past should not be overstated. Most powers, such as in the Gulf and Egypt, have had to adapt to the new circumstances, but their policy positions have not drastically altered.