Zoe Konstantopoulou was elected for first time as a Member of the Greek Parliament in May 2012 and June 2012, with the Coalition of Radical Left (SYRIZA). On 25 January 2015 she was re-elected and on 6 February 2015 was elected President of the Hellenic Parliament, obtaining a record of 235 votes.
She is also the President of the Committee on Institutions and Transparency. Subsequent to her initiative, two Committees of the Greek Parliament were recently set up: the Truth Committee on Public Debt and the Committee to promote the claim on the German (World War II) reparations, restitution the Nazi occupation loan and the claiming of the stolen archaeological treasures.
As a member of Parliament during her first term (2012-2014), she was responsible for Justice, Transparency and Human Rights Affairs for the Major Opposition (SYRIZA) and played an active role in the unveiling and/ or investigation of several large-scale corruption cases (Siemens case, Lagarde-list case, armaments- submarines case etc).