Our data demonstrating a role of neuronal Tet1 in memory extinction may have important clinical implications. Posttraumatic stress disorder (PTSD) is a common disorder caused by traumatic psychological events and characterized by an individual re-experiencing the original trauma and experiencing clinically significant distress or impairments in functioning (American Psychiatric Association, 2000, DSM-IV-TR; Porter and Kaplan, 2011, Merck Manual of Diagnosis and Therapy). Based on our findings, Tet1 may represent a potentially exciting molecular target for PTSD therapy.