Archiv: parameters / criteria / specifications / definitions / guidelines


13:02 [ CormanDrostenReview.com ]

Review report Corman-Drosten et al. Eurosurveillance 2020

(27.11.2020)

It should be noted that there is no mention anywhere in the Corman-Drosten paper of a test being positive or negative, or indeed what defines a positive or negative result. These types of virological diagnostic tests must be based on a SOP, including a validated and fixed number of PCR cycles (Ct value) after which a sample is deemed positive or negative. The maximum reasonably reliable Ct value is 30 cycles. Above a Ct of 35 cycles, rapidly increasing numbers of false positives must be expected .

PCR data evaluated as positive after a Ct value of 35 cycles are completely unreliable.

12:57 [ Weltgesundheitsorganisation - WHO.int ]

Berlin, Jan 17th, 2020: Diagnostic detection of 2019-nCoV by real-time RT-PCR

All oligonucleotides were synthesised and provided by Tib-Molbiol, Berlin. Thermal cycling was performed at 55°C for 10 min for reverse transcription, followed by 95°C for 3 min and then 45 cycles of 95°C for 15 s, 58°C for 30 s.

12:56 [ New York Times ]

Your Coronavirus Test Is Positive. Maybe It Shouldn’t Be.

(29.08.2020)

Most tests set the limit at 40, a few at 37. This means that you are positive for the coronavirus if the test process required up to 40 cycles, or 37, to detect the virus.

Tests with thresholds so high may detect not just live virus but also genetic fragments, leftovers from infection that pose no particular risk — akin to finding a hair in a room long after a person has left, Dr. Mina said.

Any test with a cycle threshold above 35 is too sensitive, agreed Juliet Morrison, a virologist at the University of California, Riverside. “I’m shocked that people would think that 40 could represent a positive,” she said.

12:51 [ DailyExpose.co.uk ]

Pandemic would end tomorrow if they stopped using the PCR test

(05.02.2021)

PCR tests look for genetic matter from the new coronavirus using amplification cycles. However, the number of amplification cycles that was needed to detect genetic matter from the virus, which is referred to as the cycle threshold, typically isn’t included in test results sent to doctors and patients. Many coronavirus tests have fairly high cycle thresholds, with most set at 40 and some set at 37. That means a number of patients who aren’t carrying much of the new coronavirus are still testing positive, even though they may not be contagious.

11:56 [ World Health Organization / Weltgesundheitsorganisation - WHO.int ]

Medical certification, ICD mortality coding, and reporting mortality associated with COVID-19, Technical note, 7 June 2020

New ICD-10 codes for COVID-19

– U07.1 COVID-19, virus identified
– U07.2 Clinically or epidemiologically diagnosed COVID-19
Probable COVID-19
Suspected COVID-19

Details of the updates to ICD-10 are available online at: https://www.who.int/classifications/icd/icd10updates/en/.

ICD-10 cause of death coding of COVID-19

Though “COVID-19” is the standard recommended terminology, certifiers may use a range of terms to describe COVID-19 as a cause of death. A list of potential terms can be found in the annex of this document. Although both categories, U07.1 (COVID-19, virus identified) and U07.2 (COVID-19, virus not identified) are suitable for cause of death coding, it is recognized that in many countries detail as to the laboratory confirmation of COVID-19 will NOT be reported on the death certificate. In the absence of this detail, it is recommended, for mortality purposes only, to code COVID-19 provisionally to U07.1 unless it is stated as “probable” or “suspected”.

11:52 [ World Health Organization / Weltgesundheitsorganisation - WHO.int ]

Global surveillance for COVID-19 caused by human infection with COVID-19 virus – Interim guidance, 20 March 2020

Case and contact definitions are based on the current available information and are regularly revised as new information accumulates. Countries may need to adapt case definitions depending on their local epidemiological situation and other factors. All countries are encouraged to publish definitions used online and in regular situation reports, and to document periodic updates to definitions which may affect the interpretation of surveillance data.

Suspect case

A. A patient with acute respiratory illness (fever and at least one sign/symptom of respiratory disease, e.g., cough, shortness of breath), AND a history of travel to or residence in a location reporting community transmission of COVID-19 disease during the 14 days prior to symptom onset;

OR

B. A patient with any acute respiratory illness AND having been in contact with a confirmed or probable COVID-19 case (see definition of contact) in the last 14 days prior to symptom onset;

OR

C. A patient with severe acute respiratory illness (fever and at least one sign/symptom of respiratory disease, e.g., cough, shortness of breath; AND requiring hospitalization) AND in the absence of an alternative diagnosis that fully explains the clinical presentation.

Probable case

A. A suspect case for whom testing for the COVID-19 virus is inconclusive.

OR

B. A suspect case for whom testing could not be performed for any reason.

Confirmed case:

A person with laboratory confirmation of COVID-19 infection, irrespective of clinical signs and symptoms.

11:28 [ Newsletter.co.uk ]

Dr Anne McCloskey: It is an alarmist distortion of the facts to say 100,000 people in the UK have died of Covid

(05.03.2021)

A new directive from the WHO to every doctor changed fundamentally how deaths were attributed. Any death, within 28 days of a positive PCR test (which Kary Mullis, the test’s inventor, and Nobel Laureate was clear should not be used as a diagnostic tool) was to be included in the Covid fatality total, regardless of the context.

Where there was no positive test, but clinical symptoms compatible with Covid 19 that is fever, shortness of breath, loss of taste and so on, likewise, attribution to the virus on the death certificate was encouraged. Autopsies ceased.

11:19 [ Office for National Statistics - .ons.gov.uk ]

Deaths registered weekly in England and Wales, provisional: week ending 19 February 2021

9. Glossary
Coronavirus (COVID-19) deaths

Coronavirus (COVID-19) deaths are those deaths registered in England and Wales in the stated week where COVID-19 was mentioned on the death certificate. A doctor can certify the involvement of COVID-19 based on symptoms and clinical findingsa positive test result is not required. Definitions of COVID-19 for deaths in Scotland and Northern Ireland are similar to England and Wales.

28.02.2021 - 08:22 [ DailyMail.co.uk ]

What IS the truth about Covid deaths? Grieving relatives along with MPs and top medics demand inquiry as families reveal MORE loved ones they believe were wrongly certified as virus victims

Grieving families last night said deaths had been wrongly certified as Covid-19.

Demanding an inquiry, top medical experts and MPs also insisted they were ‘certain’ that too many fatalities were being blamed on the virus.

One funeral director said it was ‘a national scandal’. The claims are part of a Daily Mail investigation that raises serious questions over the spiralling death toll.

22.01.2021 - 18:52 [ Weltgesundheitsorganisation - WHO.int ]

Berlin, Jan 17th, 2020: Diagnostic detection of 2019-nCoV by real-time RT-PCR

All oligonucleotides were synthesised and provided by Tib-Molbiol, Berlin. Thermal cycling was performed at 55°C for 10 min for reverse transcription, followed by 95°C for 3 min and then 45 cycles of 95°C for 15 s, 58°C for 30 s.

22.01.2021 - 18:38 [ New York Times ]

Your Coronavirus Test Is Positive. Maybe It Shouldn’t Be.

(29.08.2020)

Most tests set the limit at 40, a few at 37. This means that you are positive for the coronavirus if the test process required up to 40 cycles, or 37, to detect the virus.

Tests with thresholds so high may detect not just live virus but also genetic fragments, leftovers from infection that pose no particular risk — akin to finding a hair in a room long after a person has left, Dr. Mina said.

Any test with a cycle threshold above 35 is too sensitive, agreed Juliet Morrison, a virologist at the University of California, Riverside. “I’m shocked that people would think that 40 could represent a positive,” she said.

22.01.2021 - 18:33 [ Weltgesundheitsorganisation - WHO.int ]

WHO Information Notice for IVD Users 2020/05

Description of the problem: WHO requests users to follow the instructions for use (IFU) when interpreting results for specimens tested using PCR methodology.

Users of IVDs must read and follow the IFU carefully to determine if manual adjustment of the PCR positivity threshold is recommended by the manufacturer.

WHO guidance Diagnostic testing for SARS-CoV-2 states that careful interpretation of weak positive results is needed (1). The cycle threshold (Ct) needed to detect virus is inversely proportional to the patient’s viral load. Where test results do not correspond with the clinical presentation, a new specimen should be taken and retested using the same or different NAT technology.

17.01.2021 - 17:03 [ BMJ.com ]

Covid-19: the problems with case counting

(03 September 2020)

At the moment it seems that a polymerase chain reaction (PCR) positive result is the only criterion required for a case to be recognised.

“In any other disease we would have a clearly defined specification that would usually involve signs, symptoms, and a test result,” says Carl Heneghan, director of the Centre for Evidence Based Medicine at the University of Oxford and the editor of BMJ Evidence-Based Medicine. “We are moving into a biotech world where the norms of clinical reasoning are going out of the window. A PCR test does not equal covid-19; it should not, but in some definitions it does.”

11.01.2021 - 20:08 [ Dr Naomi Wolf / Twitter ]

Chart from @nytimes is based on absolute complete b-it. @COVID19Tracking uses unnamed „volunteers‘ to upload data, built by a magazine owned by @Bloomberg , and uses data from a hedge fund information service. 100% corrupted, a way to legally insider trade.

11.01.2021 - 19:44 [ Telegraph.co.uk ]

People with common colds testing positive for Covid-19 may simply be asymptomatic cases, experts reveal

Trademark symptoms of seasonal flu could be mistaken for symptoms of Covid-19 if the individual tests positive for the virus, it is claimed.

More than eight in ten people who test positive for coronavirus show none of the main symptoms at the time they are tested, a major study by UCL previously revealed.

However, those who test positive when they have cold symptoms may mistake them as being a part of the virus – adding to fears that it is taking a new guise as fresh strains emerge.

09.01.2021 - 18:18 [ BMJ.com ]

Covid-19: the problems with case counting

(03 September 2020)

At the moment it seems that a polymerase chain reaction (PCR) positive result is the only criterion required for a case to be recognised.

“In any other disease we would have a clearly defined specification that would usually involve signs, symptoms, and a test result,” says Carl Heneghan, director of the Centre for Evidence Based Medicine at the University of Oxford and the editor of BMJ Evidence-Based Medicine. “We are moving into a biotech world where the norms of clinical reasoning are going out of the window. A PCR test does not equal covid-19; it should not, but in some definitions it does.”

09.01.2021 - 18:12 [ Spectator.co.uk ]

The way ‘Covid deaths’ are being counted is a national scandal

(30.05.2020)

Normally, two doctors are needed to certify a death, one of whom has been treating the patient or who knows them and has seen them recently. That has changed. For Covid-19 only, the certification can be made by a single doctor, and there is no requirement for them to have examined, or even met, the patient. A video-link consultation in the four weeks prior to death is now felt to be sufficient for death to be attributed to Covid-19.

09.01.2021 - 18:02 [ Lockdown Resistance Network / Twitter ]

Enough and no more. Never in history have we behaved like this. This is psychological warfare and gaslighting. Whitty and the rest are drunk on power. I’m not complying with this nonsense. I’m not complying with this once great country becoming a totalitarian dictatorship.

13.12.2020 - 14:55 [ CormanDrostenReview.com ]

Review report Corman-Drosten et al. Eurosurveillance 2020

(27.11.2020)

It should be noted that there is no mention anywhere in the Corman-Drosten paper of a test being positive or negative, or indeed what defines a positive or negative result. These types of virological diagnostic tests must be based on a SOP, including a validated and fixed number of PCR cycles (Ct value) after which a sample is deemed positive or negative. The maximum reasonably reliable Ct value is 30 cycles. Above a Ct of 35 cycles, rapidly increasing numbers of false positives must be expected .

PCR data evaluated as positive after a Ct value of 35 cycles are completely unreliable.

13.12.2020 - 14:50 [ National Center for Biotechnology Information - ncbi.nlm.nih.gov ]

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

(23.01.2020)

All oligonucleotides were synthesised and provided by Tib-Molbiol (Berlin, Germany). Thermal cycling was performed at 55 °C for 10 min for reverse transcription, followed by 95 °C for 3 min and then 45 cycles of 95 °C for 15 s, 58 °C for 30 s.

(…)

This work was funded by European Union DG Research through projects Prepare (GA602525), Compare (GA643476), and EVAg (GA653316); by European Union DG SANCO through EVD-LabNet, as well as by the German Ministry of Research through projects RAPID (01KI1723A) and DZIF (301-4-7-01.703).

13.12.2020 - 14:41 [ WHO.int ]

Berlin, Jan 17th, 2020: Diagnostic detection of 2019-nCoV by real-time RT-PCR

All oligonucleotides were synthesised and provided by Tib-Molbiol, Berlin. Thermal cycling was performed at 55°C for 10 min for reverse transcription, followed by 95°C for 3 min and then 45 cycles of 95°C for 15 s, 58°C for 30 s.

01.11.2020 - 08:12 [ MSN.com ]

CDC: 94% of Covid-19 deaths had underlying medical conditions

(01.09.2020)

According to the CDC, comorbidity is defined as: “ more than one disease or condition is present in the same person at the same time. Conditions described as comorbidities are often chronic or long-term conditions. Other names to describe comorbid conditions are coexisting or co-occurring conditions and sometimes also “multimorbidity” or “multiple chronic conditions.“

01.11.2020 - 08:10 [ CDC.gov ]

Weekly Updates by Select Demographic and Geographic Characteristics

(today)

Table 3 shows the types of health conditions and contributing causes mentioned in conjunction with deaths involving coronavirus disease 2019 (COVID-19). For 6% of the deaths, COVID-19 was the only cause mentioned. For deaths with conditions or causes in addition to COVID-19, on average, there were 2.6 additional conditions or causes per death.

01.11.2020 - 08:05 [ Fox News ]

Richard Fowler: Americans are tired of Trump’s lies, incompetence, ignorance and failures

More than 9 million Americans have been infected with the coronavirus and more than 229,000 have tragically died. No, Mr. President, we haven’t turned the corner on this virus. The pandemic is getting worse, and the White House has been absolutely nonresponsive.

29.09.2020 - 11:32 [ CDC.gov ]

Weekly Updates by Select Demographic and Geographic Characteristics

Table 3 shows the types of health conditions and contributing causes mentioned in conjunction with deaths involving coronavirus disease 2019 (COVID-19). For 6% of the deaths, COVID-19 was the only cause mentioned. For deaths with conditions or causes in addition to COVID-19, on average, there were 2.6 additional conditions or causes per death.

29.09.2020 - 11:30 [ MSN.com ]

CDC: 94% of Covid-19 deaths had underlying medical conditions

(01.09.2020)

According to the CDC, comorbidity is defined as: “ more than one disease or condition is present in the same person at the same time. Conditions described as comorbidities are often chronic or long-term conditions. Other names to describe comorbid conditions are coexisting or co-occurring conditions and sometimes also “multimorbidity” or “multiple chronic conditions.“

20.09.2020 - 13:16 [ CDC.gov ]

Weekly Updates by Select Demographic and Geographic Characteristics

Table 3 shows the types of health conditions and contributing causes mentioned in conjunction with deaths involving coronavirus disease 2019 (COVID-19). For 6% of the deaths, COVID-19 was the only cause mentioned. For deaths with conditions or causes in addition to COVID-19, on average, there were 2.6 additional conditions or causes per death.

20.09.2020 - 13:12 [ apnews.com ]

CDC has not reduced the death count related to COVID-19

(01.09.2020)

The CDC data table is based on an analysis of death certificates that mention COVID-19 as a cause. For 6% of the deaths, COVID-19 was the only cause mentioned, the CDC notes.

The other 94% list COVID-19 and other conditions together. Among those deaths, there were, on average, 2.6 additional conditions or causes per death, the public health agency said.

20.09.2020 - 13:10 [ @honorgoesfar / Twitter ]

We would like to know why the CDC updated only 9,682 deaths silently on their Covid page. Look at the red wording? I have daily updates and it was recently added to show all these deaths were never Covid. These were underlying conditions people died from besides 9,862! #suspect

(31.08.2020)

20.09.2020 - 12:49 [ CDC.gov ]

Coronavirus Disease 2019 (COVID-19) 2020 Interim Case Definition, Approved August 5, 2020

Vital Records Criteria

A death certificate that lists COVID-19 disease or SARS-CoV-2 as an underlying cause of death or a significant condition contributing to death.

Comments

CSTE approved interim position statement Interim-20-ID-02 on August 5, 2020. Interim-20-ID-02 supersedes the first CSTE COVID-19 interim position statement, Interim 20-ID-01, which was approved on April 5, 2020.

This position statement, Interim-20-ID-02, updates the standardized case definition for COVID-19, including asymptomatic infections caused by SARS-CoV-2, and retains COVID-19 as a nationally notifiable condition. The updates clarify clinical, laboratory, epidemiologic linkage, and vital records criteria for case ascertainment and case classification based on the continued evolution of the COVID-19 pandemic. In addition, the probable case classification is updated, and a suspected case classification is added.

20.09.2020 - 12:11 [ PostAndCourier.com ]

CDC updates criteria for tracking and reporting COVID-19 cases

(15.09.2020)

however, the CDC advises against reporting out suspect cases as part of a state’s total case numbers.